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Este trabalho visa identificar os fatores associados a óbitos de adultos hospitalizadas com aids. Para isso, foi realizado estudo do tipo transversal, desenvolvido mediante dados secundários obtidos de prontuários hospitalar de 263 adultos com diagnóstico de aids em Fortaleza, Ceará. As variáveis sociodemográficas e clínicas foram consideradas preditoras e o óbito foi a variável desfecho. Foram expressas as frequências absoluta e relativa de cada variável e aplicados os testes exato de Fisher ou qui-quadrado de Pearson. Os fatores relacionados significativamente ao risco de óbito entre adultos foram: ensino fundamental incompleto (p = 0,001, OR = 1,85; IC = 1,02-3,37), estar afastado do trabalho (p = 0,039, OR = 1,59; IC = 0,81-3,23), possuir doença renal (92%; OR = 3,05; IC = 1,49-6,59), sífilis (85%; OR = 3,05; IC = 1,49-6,58), herpes simples (95%; OR = 3,98; IC = 1,16-19,01), histoplasmose (82%; OR = 0,22; I.C = 0,09-0,46), última contagem de LTCD4 < 200 (p = 0,002; OR = 3,35; IC = 1,37-9,20), queixas de dispneia e febre na admissão hospitalar (p < 0,001; OR = 0,74; IC = 0,20-2,67), tempo de internamento até sete dias (p < 0,001; OR = 0,12; IC = 0,03-0,33), primeira admissão no hospital (p = 0,002; OR = 2,15; IC = 1,31-3,55), acima de três internações no hospital (p = 0,003; OR = 3,09; IC = 1,43-6,88), ter sido internado em UTI (p < 0,001; OR = 0,12; IC = 0,04-0,28), ter realizado hemodiálise (p < 0,001; OR = 0,09; IC = 0,02-0,24), ventilação mecânica (p < 0,001; OR = 0,06; IC = 0,02-0,14) e recebido hemocomponentes e/ou hemoderivados (p < 0,001; OR = 0,18; IC = 0,10-0,32). Com esses dados, concluímos que os óbitos de adultos com aids aconteceram majoritariamente entre pessoas com condições sociodemográficas vulneráveis e com incidência considerável de doenças oportunistas, com demandas de cuidados intensivos.

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Purpose Antineoplastic treatments, mainly chemotherapy, affect the kidneys, causing toxicity, and can trigger acute and long-term chronic kidney injury. The objective of this study was to analyze the prevalence of renal disorders in patients with oncohematological neoplasms under antineoplastic treatment. Methods This is a retrospective cohort study involving 75 patients affected by hematological cancer who underwent chemotherapy between 2012 and 2108 in the Hematology Sector of the Walter Cantídeo University Hospital of the Federal University of Ceará. Sociodemographic and clinical data, blood biochemical assessment, and Glomerular Filtration Rate (GFR) were analyzed using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. The data were tabulated, transferred to the Statistical Package for the Social Sciences software, version 20.0, and analyzed using Fisher's exact test or Pearson's chi-square test, followed by the Mann-Whitney test. Additionally, the variables were treated using a multinomial logistic regression model (p <0.05). Results The prevalence of renal disorders was 52.4%, considering the episodes of GFR through the CKD-EPI equation. There was an association between the reduction in GFR and the variables: female gender (p = 0.002), diagnosis of multiple myeloma (p = 0.008), start of treatment within 40 days (p = 0.005), protocol Cyclophosphamide, Oncovin, Prednisone (p = 0.026), Idarubicin (p = 0.032), Vidaza protocol, Dexamethasone, Cyclophosphamide (p <0.001), Zoledronate (p <0.001) and Pamidronate (p = 0.012). It was also observed that the Cancer and Leukemia Group B protocol (p <0.001) is inversely associated with a reduction in GFR. Conclusions The prevalence of renal disorders is high in the service evaluated, requiring periodic monitoring of the evaluation of renal function, since the reduction in GFR is statistically associated with different protocols used.

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