Aeromagnetic data acquired over part of the Anambra Basin is analyzed to determine the structural pattern and sedimentary thickness of the basin. The study area is covered by high resolution aeromagnetic data on sheets 301 (Udi), 302 (Nkalagu), 312 (Okigwe) and 313 (Afikpo), and lies between latitudes 5o30’0’‘-6o30’0’‘ and longitudes 7o0’0”-8o0’0”. The whole area was divided into 25 overlapping blocks of 37.2km2 each and a 2D energy spectral analysis was carried out. Total magnetic intensity data was subjected to filtering and analytical techniques to determine the structural pattern, mineralization potential, depth to the basement, variation in the sedimentary thickness. The structural map generated using the vertical derivatives shows that the major structural orientation of the area is in the ENE-WSW trend and the minor trend is the NW to SE direction widespread all over the area. These structures are as a result of the various near-surface magnetic intrusion within the study area. The spectral analysis result shows two depth layers, the deep and the shallow depth, the depth to magnetic basement for the deep anomalous source ranges from 3.3km to 4.8 4km with an average depth of 3.99km, while the depth to shallow magnetic sources ranges between 0.46km to 0.67km and an average of 0.56km within the area. The mineralization pattern in this area follows the ENE-WSW direction.