Our results demonstrate consistent anti-inflammatory and anti-proliferative activity and assign TTHL as a valuable tool in the development of a new treatment for skin inflammatory and proliferative diseases, such as psoriasis.

Ferulic acid (FA) is a phenolic compound with well-known antioxidant potential that can be used as a promising anti-inflammatory and anti-cancer molecule. Furthermore, it has been reported to have neuroprotective activity. One of the main problems, which limit its clinical use, is its low bioavailability when administered orally. This limitation can be circumvented by changes in their structure and/or for preparing lipid-based formulations. The aim of this study was to synthesize a derivative of FA, the hexadecyl ferulate (HF). This compound would be more susceptible to pass through blood-brain barrier (BBB) due to its lipophilic character. The HF was obtained by Steglich esterification and yielded 76.77 ± 1.35%. Its structural characterization was performed by spectroscopic methods of Fourier-transformed infrared spectroscopy (FTIR) and nuclear magnetic resonance (NMR). FTIR spectrum of HF presented two typical bands of ester group, a C=O ester stretching band at 1725 cm-1 and a CO stretching band at 1159 cm-1. The 1 H and 13 C spectral data confirmed the chemical structure of HF. Regarding the 13 C NMR spectrum, HF showed a chemical shift at δ 167.39 ppm which corresponded to the carbonyl carbon of the ester group. Concerning the in vitro antioxidant potential, HF had equivalent or improved scavenger activity than FA leading to IC50 values of 0.083 ± 0.009 nmol.mL-1 and 0.027 ± 0.002 nmol.mL-1 in DPPH radical scavenging and ABTS radical cation decolorization assays, respectively. Further studies are required in order to investigate the antioxidant effect of HF in biological media.

Silsesquioxane 3-n-propylpyridinium chloride (SiPy + Cl -) is a water-soluble polymer that can be used as a promising material with remarkable biological effects. SiPy + Clcan form thin films on substrate surfaces and shows suitable adhesiveness. Besides, it has high affinity for metal ions. Considering this effect as exchanger polymer and the well-known antimicrobial and cytotoxic features of copper, the aim of this study was to perform the copper functionalization of silsesquioxane 3-n-propylpyridinium chloride Cu-SiPy + Cl − . The HIGHLIGHTS• Silsesquioxane 3-n-propylpyridinium chloride (SiPy + Cl -) was synthesized.• Copper functionalization of SiPy + Clwas performed to obtain Cu-SiPy + Cl -.• Antimicrobial and cytotoxic effects of SiPy + Cland Cu-SiPy + Clwere demonstrated.• Cu-SiPy + Clshows a promising use in oral care products.

Levar às crianças uma visão atualizada sobre o que é ciência e o que é ser pesquisador, como se dá a pesquisa e seus resultados definiu o escopo deste projeto. Denominado "Transformação da sociedade através da ciência", se apoiou na necessidade de comunicação do meio acadêmico com a comunidade externa, sobretudo, com estudantes, desde os anos iniciais do ensino fundamental e seus professores, de forma a ampliar a promoção do acesso aos conhecimentos científicos e tecnológicos. O objetivo deste projeto foi integrar o Programa de Pós-graduação com a Comunidade externa, intensificando suas ações de inserção social, e sensibilizar alunos dos anos iniciais do ensino fundamental para o interesse pela ciência e pela carreira científica. O público alvo foi composto de 120 alunos do 2º e 3º ano do ensino

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