The act of suicide is commonly viewed as wrong in some sense, but it is not clear why this is. Based on past empirical research and philosophical theorizing, we test ten different explanations for why suicide is opposed on normative grounds. Using a within-subjects design, Study 1 showed that seven out of ten manipulations had significant effects on normative judgments of suicide: time left to live, lack of close social relationships, a history of prior immoral behavior, the manner in which the suicide is committed, painful, incurable medical issues, impulsive decision-making, and the actor’s own moral-religious background. However, in all cases, the act of suicide was still considered wrong, overall. Using a between-subjects design, Study 2 tested the combined effect of the seven significant manipulations from Study 1. In combination, the seven manipulations eliminated opposition to suicide, on average. Implications for moral psychology and suicide prevention are discussed.