Introdction: Haematological parameters are useful in making diagnosis of diseases and also help in the antenatal assessment of women during pregnancy. The physiological changes of pregnancy, due to the influence of hormones such as oestrogen, progesterone also affect haematological indices when compared with the non-pregnant state. Aim: The study investigated haematological indices in pregnant women with plasmodiasis attending antenatal clinics in Primary health care centre Ozuoba, Port Harcourt. Methodology: This was a cross sectional study, which recruited a total of one hundred (100) subjects, of which (40) were non parasitized pregnant women who served as control, while (60) were parasitized pregnant women who served as test. The samples were analyzed for haematological parameters using (Sysmex XP-300), while microscopy was used to investigated for the presence of malaria parasite. Result: Comparing the hematological parameters of the study population at different level of plasmodiasis, showed that WBC, and Neutrophil were significant with p-Value of 0.001 and 0.0089 respectively at P<0.05. The other haematological parameters such as, Red Blood Cell, Haemoglobin, Haematocrit, Mean Cell Volume, Mean Cell Haemoglobin, Mean CellHaemoglobin Concentration, Platelet, Plateletcrit, Neutrophils, lymphocyte, monocyte, eosinophil and basophil showed no statistical significant difference at p<0.05. While comparison of the haematological parameters of the study group according to parity showed that WBC count had statistical significance with a p-Value of 0.0035 at p<0.05. Conclusion: Findings from this study has shown that there was statistical significant difference in the white blood cell count of malaria-parasitized pregnant subject. It was further revealed that there was no statistical significant difference in the other haematological parameters. The reason for the pattern of result obtained is that some of the pregnant women may have been receiving prophylactic antimalarial drugs before their recruitment, this will in turn minimize the impact of malaria infection on some haematological parameters.

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Background: Pregnancy is the fertilization and development of an embryo or fetus in a woman's uterus. It is a critical stage of development during which maternal nutrition can strongly influence obstetric and neonatal outcomes. The aim of this study was to determine the effect of pregnancy on some coagulation and haematological parameters of pregnant women residing in Port Harcourt, Nigeria. Method: This case-control study investigated 80 pregnant subjects and 20 non-pregnant controls. Haematological parameters were determined using a fully automated The SysmexXP-300, while the coagulation parameters (PT and INR) were determined with the automated method. Results: The mean PT (s), HB (g/dl), PCV (%), PLT (x109/L), RBC (mcL), LYMPH (%), BASO (%) and EOSIN (%) counts were significantly lower among the pregnant subjects (5.02±5.82, 11.00±1.13 g/dl and 33.81±3.89%, 189.6±52.93 × 109/L, 3.95±0.50, 43.93±10.10 %, 0.9385±1.08 % and 1.12±1.32 %) compared to the non-pregnant controls (1.68±2.37, 12.01±1.29 g/dl, 37.31±3.39 %, 235.6±72.37 × 109/L, 4.45±0.35, 43.24±9.06, 2.11±0.94 and 2.15±1.47) respectively. There were no significant differences in the INR, MONO (%), MPV (fl), MCV (L/C), and MCH (g/c) between the pregnant subjects (0.92±0.11, 5.41±2.59 %, 11.67±4.848, 84.26±3.77 and 28.06±3.54) and non-pregnant controls (0.88±0.11, 5.58±2.65, 11.14±5.45, 82.52±10.45 and 26.96±1.85). The NEUT (%), PDW (%) and WBC (x109/L) were significantly higher among the pregnant subjects (44.90±11.24 %, 13.26±2.56 % and 8.35±2.982 x109/L) compared to the non-pregnant controls (46.63±9.96 %, 10.78±1.80 % and 4.71±0.81 x109/L). Conclusion: This study has shown that pregnancy has a significant effect on some haematological and coagulation parameters of pregnant women in Port Harcourt. The result of this research work indicates the need to routinely monitor the complete blood count, thrombocytopenia and hyper-coagulative activity among pregnant women of African descendant.