Background: Skin cancer can quickly become fatal. An examination and biopsy of dermoscopic pictures are required to determine if skin cancer is malignant or benign. However, these examinations can be costly. Objective: In this research, we proposed deep learning (DL)-based approach to identify a melanoma, the most dangerous kind of skin cancer. DL is particularly excellent in learning traits and predicting cancer. However, DL requires a vast number of images. Method: We used image augmentation and transferring learning to categorise images into benign and malignant. We used the public ISIC 2020 database to train and test our models. The ISIC 2020 dataset classifies melanoma as malignant. Along with the categorization, the dataset was examined for variation. The training and validation accuracy of three of the best pre-trained models were compared. To minimise the loss, three optimizers were used: RMSProp, SGD, and ADAM. Results: We attained training accuracy of 98.73%, 99.12%, and 99.76% using ResNet, VGG16, and MobileNetV2, respectively. We achieved a validation accuracy of 98.39% using these three pre-trained models. Conclusion: The validation accuracy of 98.39% outperforms the prior pre-trained model. The findings of this study can be applied in medical science to help physicians diagnose skin cancer early and save lives.   Keywords: Deep Learning, ISIC 2020, Pre-trained Model, Skin Cancer, Transfer Learning

Skin cancer is an uncommon but serious malignancy. Dermoscopic images examination and biopsy are required for cancer detection. Deep learning (DL) is extremely effective in learning characteristics and predicting malignancies. However, DL requires a large number of images to train. Image augmentation and transferring learning were employed to overcome the lack of images issue. In this study we divided images into two categories: benign and malignant. To train and test our models, we used the public ISIC 2020 database. Melanoma is classified as malignant in the ISIC 2020 dataset. Along with categorization, the dataset was studied to demonstrate variation. The performance of three top pretrained models was then benchmarked in terms of training and validation accuracy. Three optimizers were employed to optimize the loss: RMSProp, SGD, and ADAM. Using ResNet, VGG16, and MobileNetV2, we obtained training accuracy of 98.73%, 99.12%, and 99.76%, respectively. Using these three pretrained models, we attained a validation accuracy of 98.39%.