Newborn babies constitute the foundation of life. The birth of a baby is one of the most awe inspiring and emotional events that can occur in one’s life time. In India most the mothers are not aware of management regarding minor disorder of newborn (vomiting, diarrhea, physiological jaundice conjunctivitis, umbilical cord infection, skin rashes etc). Mother plays an important role in the identifying minor developmental deviation and early evidences of the disease process because she is constantly and closely watching her baby. Methodology: pre experimental (one group pretest and posttest) design was adopted for this study. The study was conducted at postnatal ward AIIMS Raipur with sample size of 30 primipara mothers. Non probability convenient sampling technique was adopted to select the sample. The data was collected by means of self-structured questionnaire to assess the knowledge among primipara mothers. Result: The mean score of pre-test was 15.36 and mean score of post-test was 22.4 and the mean improvement was 7.04, which is 45.83% of total primipara mothers. The paired ‘t’ value obtained for knowledge was 10.41 which was found significant at 0.05 level (p<0.05) which is 2.05. Which result shows that significantly an improvement in the knowledge of the primipara mothers after the structured teaching programme (STP) on selected minor ailments of newborn.