Inflammation involving the innate and adaptive immune systems is a normal response to infection. However, when allowed to continue unchecked, inflammation may result in autoimmune or autoin-flammatory disorders, neurodegenerative disease, or cancer. A variety of safe and effective antiinflammatory agents are available, including aspirin and other nonsteroidal anti-inflammatories with many more drugs under development. Other anti-inflammatories currently in use or under development include statins, histone deacetylase inhibitors, PPAR agonists, and small RNAs. Anti-inflammatory and Antioxidant activities of the aqueous (CFA) were assayed in wistar albino rats. The extracts were found to posses significant anti-inflammatory effect in both acute and chronic models. Cassia fistula Linn has many therapeutic uses. Therefore, we aimed to study its anti-inflammatory activity. The aqueous extract of dried fruits of Cassia fistula Linn was prepared. The antiinflammatory activity of these extracts was investigated using the CFA-induced paw edema model in rats. It was observed that extracts of dried fruits Cassia fistula Linn showed anti-inflammatory activity. This aqueous extract showed maximum antiinflammatory activity at 400 mg/kg dose. It showed maximum percentage inhibition of 41.15%, which was comparable with the positive control, diclofenac sodium, which showed 47% inhibition. Further, the acute toxicity study with the extracts showed no sign of toxicity up to a dose level of 2000 mg/po. Thus it could be concluded that cassia fistula bark extracts (CFA & CFM) possess significant antiinflammatory and anti oxidant properties. The present study reveals that the aqueous extracts of fruit of Cassia fistula Linn can be used as anti-arthritic drug.
The growing phenomenon of antibiotic resistance, particularly to pathogenic microorganisms, in current medicine, has directed the concern of scientists for finding novel antimicrobial agents from plant origin with negligible side effect. The present study was aimed to phytochemical investigation and antimicrobial activity of seed extract of Datura stramonium in sequentially with different organic solvents. For this, antimicrobial properties were tested against bacteria Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumonia and Bacillus subtilis by cup plate method. Among the tested bacterial Klebsiella pneumoniae was the most inhibited majorly with the chloroform extract. Datura stramonium chloroform seed extract produced maximum zone of inhibition 26 mm against Klebsiella pneumoniae and 12 mm against Bacillus subtilis and 13 mm against Escherichia coli. Datura Stramonium methanol seed extract produced maximum zone of inhibition 27 mm against Pseudomonas aeruginosa and 15 mm against Bacillus subtilis, 14 mm against Staphylococcus aureus and 19 mm against Escherichia coli. Datura stramonium petroleum ether seed extract produced 16 mm zone of inhibition against Escherichia coli. Datura stramonium aqueous seed extract exhibits 24 mm zone of inhibition against Bacillus subtilis. All the experienced solvent extracts showed potential antimicrobial activity Index against various tested microorganisms. Owning to the results, it can be concluded that the extracts of the Datura stramonium can be used to design different herbal antimicrobial agents.
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