To obtain the seismic performance of plate-shell integrated concrete liquid-storage structures (PSICLSS), a scale test model was built for shaking table testing. A combination isolation layer is proposed, and the dynamic responses of non-isolation and combination isolation PSICLSS under unidirectional and bidirectional earthquakes were tested. The results show that the combination isolation layer can change the spectral characteristics of the input acceleration, reducing the acceleration response and displacement of the structure, but it will increase the hydrodynamic pressure and liquid sloshing height. Under earthquake action, the liquid sloshing of combination isolation PSICLSS clearly appears as a nonlinear splash phenomenon. When considering the vertical earthquake, the horizontal acceleration response of PSICLSS and the liquid sloshing height change little, the peak hydrodynamic pressure changes significantly, and the peak position also changes. The maximum displacement of the isolation layer increases, but the residual displacement decreases.