Multisystem disorders of unknown aetiology characterized by development of HTN to the extent of 140/90 mm Hg or more with Proteinuria after 20 th wk of pregnancy in a previously normotensive and non proteinuric patient. May appear before 20wks in cases of hydatidiform mole, acute polyhydramnios and multiple pregnancies. BP≥ 140/90 mm Hg before pregnancy or diagnosed before 20 weeks gestation not attributable to gestational trophoblastic disease (OR) Hypertension first diagnosed after 20 weeks gestations and persistent after 12 weeks postpartum. In chronic HTN, the foetus is more prone for growth restriction, preterm delivery, and death of foetus. 50% of the cases belong to The Labetalol Group, while the other 50% comprise The Nifedipine Group, selected randomly. Each group comprised a total of 62 cases, 50 of them are Mild PIH cases while the other 12 cases are the cases of Severe Hypertension, Imminent Eclampsia, Eclampsia, Placental Abruption etc. Most of the cases of Labetalol Group progressed up to term, of which one case crossed the EDD. This woman was discharged at her request and she reported to the hospital only after crossing the EDD. As many as 69.35% (43 cases) delivered vaginally in Labetalol Group, whereas the Caesarean section rate for Nifedipine group is about 48.39%. Emergency Caesarean section rate was 25.80% in Labetalol group where as it was 37.10% in the Nifedipine Group.
In pregnancy, if diastolic blood pressure rises above 110mmHg, and does not settle with rest, there is increase in danger to both mother and foetus with potential fatal complication of cerebro vascular accidents, eclampsia and placental abruption in mother and IUGR and increased perinatal mortality in foetus. One hundred and twenty four cases of Pregnancy Induced Hypertension were studied during the period of 2 years at the Department of Obstetrics and Gynaecology, Government General Hospital, a Teaching Hospital attached to Medical College. 30.65% of Labetalol group were preterm deliveries where as 43.55% of Nifedipine group delivered preterm. Intra Uterine Growth Retardation was 6.45% with Labetalol and 4.83% with Nifedipine. Over all Perinatal Mortality was 11.29% with Labetalol and 19.35% with Nifedipine.
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