No abstract

Vitamin D is the generic term for two molecules, ergocalciferol (vitamin D 2) and cholecalciferol (vitamin D 3). The former is derived by UV irradiation of the ergosterol, which is widely distributed in plants and fungi, whereas the latter is formed from the action of UV irradiation on the skin (1). There are few dietary sources of vitamin D. Vitamin D deficiency has been associated with insulin resistance, b-cell dysfunction and reduced insulin secretion. It has also been implicated as a risk factor for metabolic syndrome, hypertension and types 1 and 2 diabetes, all of which may explain its links with increased CVD (2). These findings are particularly apparent in Asian groups and may underlie the considerable predisposition to CVD in this group (3). There is evidence to suggest that vitamin D deficiency is associated with raised serum total cholesterol and LDL-cholesterol and inversely related to the serum concentration of cardioprotective HDL (4) , although this relationship needs to be more widely confirmed in well-controlled cohort and intervention studies. The D-FINES Study is currently investigating the effect of diet and sunlight exposure on vitamin D status in women aged 19-70 years. Fasted blood samples were collected every 3 months from summer 2006 to spring 2007 for a total of 227 Caucasian and seventy-two Asian women and dietary intake assessed using 4 d estimated food records. The aim of the present subsidiary study was to determine the association between dietary intake of vitamin D and serum lipid profiles, including TAG, LDL-and HDL-cholesterol and LDL :HDL.

Bone mineral density (BMD) is the measure of the absolute amount of bone. It correlates well with the general health of the bone, its strength and its ability to bear weight (1) . The measurement of BMD allows for the prediction of fracture risk (2) . Little is known about the effect of ethnicity on diet, physical activity and BMD. Thus, the principal aim of the present study was to investigate the effect of season and ethnicity on axial and peripheral BMD in UK pre-and post-menopausal women. The specific objective was to determine whether there was a seasonal variation in lumbar spine and femoral neck (FN) BMD in Caucasian and Asian women living in the UK.The BMD data were collected from the D-FINES study, which included seasonal data on 242 Caucasian and seventy-two Asian women aged 19-70 years (mean age (years) 50.4 (SD 14.3) and 49.7 (SD 11.6 respectively) over a period of 12 months. Women were randomly recruited through general practitioners or through Asian community networks in Woking, Kingston and Thornton Health. BMD was measured in autumn 2006 (September-December) and spring 2007 (March-June) by dual X-ray absorptiometry (QDR; Hologic Inc., Bedford, MA, USA). Other measurements undertaken included data on dietary intake and fasted blood samples for assessment of vitamin D status. Ethnicity . . . Caucasian Asian Autumn Spring Autumn Spring Mean SD Mean SD Mean SD Mean SD FN BMD (g/cm 2 ) 0.792 a 0.109 0.787 b 0.111 0.805 0.104 0.806 0.113 FT BMD (g/cm 2 ) 0.807 a 0.122 0.714 b 0.100 0.709 0.123 0.713 0.162 FW BMD (g/cm 2 ) 0.672 0.152 0.676 0.153 0.675 0.133 0.683 0.139 F total T score -0.346 0.984 -0.398 0.958 -0.227 0.839 -0.255 0.875 FT, femoral trochanter; FW, femoral Ward's triangle; F, femoral. a,b Values with unlike superscript letters were significantly different (paired t test; P < 0.05).The Table shows that in Caucasian women autumn BMD was significantly higher when compared with spring BMD at the hip BMD sites, which remained significant after adjustment for dietary Ca and vitamin D intake. However, no seasonal differences were found in the Asian women. The novel seasonal data in ethnic groups may possibly be explained by variations in vitamin D (25-hydroxyvitamin D) status (3) in Caucasian women but not Asian women and this finding requires further investigation. Analysis is now underway to explore the association between bone health, anthropometrics and vitamin D metabolism (including 25-hydroxyvitamin D status, parathyroid hormone and serum Ca) in the D-FINES dataset.