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Increasing demand of high-speed portable modules for multimedia applications has motivated the development of hardware-based solutions for image processing applications. Most of the nonrigid image registration algorithms are found to be unsuitable for hardware implementation because of their nonlinearity and computationally intensive nature. In this paper, an algorithm for nonrigid image registration based on Demons approximation is proposed. The algorithm has been simulated in MATLAB and results show a 15% improvement in peaksignal-to-noise-ratio with a 17% reduction in registration time for 256 × 256 image over the original Demons algorithm. The proposed algorithm is synthesized in Virtex6-xc6vlx760-2-ff1760 and maximum synthesized frequency is found to be 174 MHz. The proposed architecture provides the low cost, high-speed solution for the registration process, which is also helpful for making a portable system. Index Terms-Demons algorithm, image registration, nonrigid registration.1063-8210

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The study was aimed to evaluate the performance of a newly developed spectroscopy-based non-invasive and noncontact device (SAMIRA) for the simultaneous measurement of hemoglobin, bilirubin and oxygen saturation as an alternative to the invasive biochemical method of blood sampling. The accuracy of the device was assessed in 4318 neonates having incidences of either anemia, jaundice, or hypoxia. Transcutaneous bilirubin, hemoglobin and blood saturation values were obtained by the newly developed instrument which was corroborated with the biochemical blood tests by expert clinicians. The instrument is trained using Artificial Neural Network Analysis to increase the acceptability of the data. The artificial intelligence incorporated within the instrument determines the disease condition of the neonate. The Pearson’s correlation coefficient, r was found to be 0.987 for hemoglobin estimation and 0.988 for bilirubin and blood gas saturation respectively. The bias and the limits of agreement for the measurement of all the three parameters were within the clinically acceptance limit.