No abstract

No abstract

Fused pyridine derivatives R 0450 Multicomponent Synthesis of Imidazo[1,2-a]pyridines Using Catalytic Zinc Chloride. -The three-component reaction of 2-aminopyridine, aldehydes and isonitriles proceeds either under microwave or thermal conditions. Zinc chloride is found to be a novel catalyst for this type of transformation. -(ROUSSEAU*, A. L.; MATLABA, P.; PARKINSON, C. J.; Tetrahedron Lett. 48 (2007) 23, 4079-4082; Discovery Chem., CSIR, Biosci., Modderfontein 1645, S. Afr.; Eng.) -Mais 38-147

Binding of aluminium to acetylcholine has important biological implications particularly in Alzheimer's disease. An electrochemical technique, adsorptive cathodic stripping voltammetry, has been employed in this study to investigate the in‐situ formation of a complex between aluminium and acetylcholine. The stability of the resulting complex was compared with that of the in‐situ complexes formed between acetylcholine and sodium or calcium. From the shifts in the reduction potential of the metals on addition of acetylcholine it is concluded that a strong complex is formed between acetylcholine and aluminium. Much weaker complexes are formed between calcium or sodium and acetylcholine. These results have important implications in the aetiology of Alzheimer's disease‐in which brain aluminium concentrations are known to be high and brain cholinergic function is lower than normal.