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Background: Majoon-Najah is a composite Unani formulation that consists of multiple medicinal plants and is advised for neurological illnesses. Several studies were carried out on Majoon-Najah (MN) and its ingredients to evaluate the protective effect against seizure and antidepressant activity in animals using a classical form as well as extract. Terminalia bellerica and Emblica officinalis are the major constituents of MN. Scientifically documented literature summarises the hepatoprotective potential of these constituents. Aim: The current study aimed to evaluate the possible hepatoprotective, antioxidant and anti-inflammatory perspective of traditional Indian Unani formulation MN and Majoon-Najah hydro-alcoholic extract (MNHE) in a Guinea pig model. Methods: Thirty adult male albino guinea pigs were randomly assigned into five groups for this study. MN and MNHE were given intragastrically for 15 days, followed by intraperitoneal Cadmium chloride (CdCl2, 3 mg/kg/day) from days 8 to 15, as per the schedule. Blood samples were taken from the heart on the 16th day, and the liver was operated on for biochemical analysis and histopathology under complete anesthesia. Results: CdCl2 changed the levels of liver function markers, serum biochemical indicators like albumin, total protein, glucose, and cholesterol in the blood; lipid peroxidation (MDA), glutathione reductase (GSH), superoxide dismutase (SOD), and glutathione peroxidase (GPX) in hepatic tissue homogenate, pro-inflammatory cytokines level and liver cytoarchitecture. MN and MNHE were found to protect guinea pigs’ liver from CdCl2-induced injury by lowering raised parameters and increasing enzymatic antioxidants. MN and MNHE did not significantly heal injured liver tissues caused by CdCl2 in histopathological examinations. Conclusion: CdCl2 induces hepatotoxicity that is likely to worsen with increasing dosage and duration of exposure. MN and MNHE exert their hepatoprotective action by scavenging free radicals, decreasing malondialdehyde levels, activating antioxidant enzymes, and down-regulating proinflammatory indicators.

Background: The use of medicinal plants is vital in the treatment of several ailments. Litchi (Litchi chinensis Sonn.) fruit pericarp is the main by-product of litchi processing. Litchi fruit pericarp contains a significant amount of polyphenolic compounds, which have been found to have a broad variety of biological activities. Method: Litchi pericarp was produced in 10% (w/w) hydrogel and tested for wound healing activities in Wistar rats using an excision wound model. Wound healing activity was evaluated using wound-healing rate, inflammatory cytokine levels, oxidative stress, collagen hydroxyproline and hexosamine concentration, and macroscopic and histological evidence. Results: The results show that pericarp extract has significant wound healing potential, which is indicated by better wound closure, tissue regeneration, and histological characteristics. Litchi pericarp hydrogel boosted the skin's hydroxyproline content, antioxidant capacity, wound contraction, and anti-inflammatory potential by regulating the production of the cytokines TNF-α, IL-1β, and IL-6. This supports the effectiveness of litchi pericarp's wound-healing qualities. Conclusion: Litchi pericarp hydrogel promoted wound recovery in rats, encouraging its application in wound alleviation.