Purpose Maintaining adherence to antipsychotic (AP) medication is often challenging. Aripiprazole tablets with sensor (AS) contain an ingestible event marker and communicate with wearable patches and a smartphone app to provide objective medication ingestion data. This study evaluated real-world treatment patterns of AS usage and its impact on psychiatric healthcare resource utilization (HCRU). Patients and Methods This retrospective, observational cohort study identified individuals who initiated AS between 1/1/2019 and 6/30/2020 with 3 months baseline and 6 months of follow-up data using a commercial medical and pharmacy claims database (Clarivate). Controls were propensity score-matched (4:1) to AS initiators based on age (±2 years), sex, diagnosis (major depressive disorder [MDD], schizophrenia, bipolar I disorder [BP-I], other), insurance, and baseline oral AP use (yes/no). Days of AP supply were evaluated using a general regression model. The frequency of psychiatric HCRU during follow-up was compared between groups using a zero-inflated regression model. Results Most AS initiators were diagnosed with MDD (61.2%) and were women (61.2%); mean age was 37.7 years (standard deviation: 14.1). Most AS initiators (53.1%) continued treatment for >60 days (mean days of supply = 77). After adjusting for covariates, AS initiators had 41% more days of AP supply during follow-up compared with controls ( P <0.0001) and significantly lower adjusted odds ratios (ORs) for psychiatric outpatient visits (adjusted OR = 0.80; P <0.05), emergency department visits (adjusted OR = 0.11; P <0.05), inpatient visits (adjusted OR = 0.42; P <0.05), and other medical services (adjusted OR = 0.25; P <0.05). Conclusion Participants who implemented AS had significantly more days of AP supply and fewer psychiatric care visits. These preliminary results suggest AS usage can help build regular medication-taking habits and holds promise for reducing psychiatric HCRU. Additional studies with larger sample sizes are warranted to inform clinical practice and coverage decisions.

Background: Though rarely diagnosed with Rett syndrome, males account for 3–5% of all cases in the USA. Nevertheless, few studies have examined characteristics of males with Rett syndrome and their healthcare service utilization using commercially available healthcare claims data. Objective: Improve understanding of healthcare service utilization and cost associated with the population of males with Rett syndrome. Methods: Data were integrated medical and pharmacy claims. Male individuals with more than two claims with a primary diagnosis of Rett syndrome were stratified into age groups (<5 years; ≥5 and <10 years; and ≥10 years). Patient descriptions, comorbidities, service utilization and cost were measured. Results: Mean age was 20.4 years and most patients had Medicaid. Epilepsy, incontinence, dyspnea and dysphagia were common comorbidities during follow-up. Individuals averaged 6.7 office visits, 4.1 outpatient visits, 2.2 emergency admissions and 4.5 inpatient admissions per year. Occupational therapy was used more than physical and speech therapy. Conclusion: The study improves understanding of males with Rett syndrome within a commercially available dataset.

Aim: To date, no studies have used a commercially available claims dataset to examine the characteristics, conditions, and healthcare service utilization of individuals with Rett syndrome. Objective: To improve understanding of the Rett population using data available to health insurance plans. Methods: Data were integrated medical and pharmacy claims from the Real-World Evidence data repository licensed from the Decision Resources Group. Individuals had claims for >2 visits which included a diagnosis of Rett and were stratified into three age groups: 1 (<5 years), 2 (>5 and <10 years) and 3 (>10 years). Co-occurring conditions and healthcare service utilization were measured. Diagnoses prior to Rett were evaluated. Results: Most were female. Epilepsy, incontinence, and scoliosis were common co-occurring conditions. Individuals averaged 4.6 office and 2.5 outpatient visits, and 2.1 emergency and 2.9 inpatient admissions. Group 1 used more physical, occupational and speech therapy and averaged more inpatient days compared with others (p < 0.05). Conclusion: This study improves understanding of Rett using data that is typically available to health insurance companies.

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