This study aims to see the differences in student chemistry learning outcomes who apply the Learning Cycle 5E learning model with Guided Discovery Learning using learning video media on ion balance material in salt solution in class XI MIA SMAN 08 Bengkulu City. The research was conducted in February -July 2019 for the 2018/2019 academic year. This type of research is quasi-experimental research. The population of this study were all students of class XI MIA, totaling 136 students. Sampling was carried out after testing for normality and homogeneity. After testing for normality and homogeneity, the sample was determined using a random sampling technique of two classes. Experimental class 1, namely class XI MIA 3, with 34 students applying the Learning Cycle 5E learning model, while experimental class 2, namely class XI MIA 4, amounting to 35 students applying the Guided Discovery Learning learning model. Data on student learning outcomes were obtained from pre-test and post-test scores.test and data were processed using normality test, homogeneity test and hypothesis testing with a significant level of 0.05. In general, the results of the research show that the two learning models applied can improve student learning outcomes and have reached the standard KKM score of 75. Classes that apply the Learning Cycle 5E learning model get higher learning outcomes than classes that apply the Guided Discovery Learning learning model. The average post-test scores for experimental class 1 and experiment 2 are 82.35 and 77.14, which means that the post-test scores have reached the standard KKM scores, then the difference between the average pre-test and post-test scores for the experimental class 1 and Experiment 2 are 57.06 and 52.57. Based on the difference in the average value of the pre-test and post-test experimental class 1 is higher than the experimental class 2. Hypothesis testing is obtained a significance value of > 0.05, which is 0.214. The results of the hypothesis test concluded that there was no significant difference between the class that applied the Learning Cycle 5E learning model and the class that applied the Guided Discovery Learning learning model using instructional video media.