Seven isoquinoline alkaloids isolated from the bark of Actinodaphne macrophylla in this study demonstrated in vitro antiplasmodial activities against Plasmodium falciparum 3D7 with IC 50 values of 0.08 μM, 0.05 μM, 1.18 μM, 3.11 μM, 0.65 μM, 0.26 μM, and 1.38 μM for cycleanine, 10demethylxylopinine, reticuline, laurotetanine, bicuculine, -hydrastine and anolobine, respectively, which are comparable with the reference standard, chloroquine. 10-Demethylxylopinine was found to be the most active of these compounds.

The Persea declinata (BI.) Kosterm belongs to the family Lauraceae, is another Persea species with potential medicinal values. It is widely distributed in Borneo, Java, Malaysia (Penang, Kelantan, Terengganu, Pahang, Selangor) and Singapore. It shares the same genus with the infamously studied Persea americana, or better known as the avocado, however, there are no documentation of this plant being investigated chemically or biologically. This paper will discuss the antioxidant and anticancer activities of the crude extract and fractions of Persea declinata (BI.) Kosterm through DPPH and ORAC assay, and MTT assay using human breast carcinoma cells (MCF-7), human non-small cell lung cancer cells (A549) and human normal hepatic WRL-68 cell type.

Abstract:The Persea declinata (Bl.) Kosterm belongs to the family Lauraceae, is another Persea species with potential medicinal values. It is widely distributed in Borneo, Java, Malaysia (Penang, Kelantan, Terengganu, Pahang, Selangor) and Singapore. It shares the same genus with the infamously studied Persea americana, or better known as the avocado, however, there are no documentation of this plant being investigated chemically or biologically. This paper will discuss the antioxidant and anticancer activities of the bark crude extract and fractions of Persea declinata (Bl.) Kosterm through DPPH and ORAC assay, and MTT assay using human breast carcinoma cells (MCF-7), human non-small cell lung cancer cells (A549) and human normal hepatic WRL-68 cell type.