Background: The COVID-19 pandemic has led to global health crisis. Most studies have focused on evaluating the effects of COVID-19 on the general population, and there is still insufficient data on its impact on vulnerable populations, such as pregnant women. The study evaluates maternal and perinatal outcomes on pregnant women with COVID-19 in Kariadi as tertiary hospital in Central Java.Methods: We prospectively collected and analyzed data for a cohort of 45 pregnant patients with COVID-19 between March 31st and September 23th 2020 in Kariadi hospital.Results: A total of 45 pregnant women with COVID-19 delivered 46 babies including one twin pregnancy. The symptoms ranged from asymptomatic (54.3%), mild (26.6%), moderate (8.8%), severe (2.2%), and critical (6.6%). Gestational age was 22 to 41 weeks. Cesarean section was the most mode of delivery (86.7 %). Diabetes in pregnancy and HIV were the most common comorbidities found in this study, there were also seven patients came with preeclampsia. There were three maternal mortalities, we reported one maternal death (2.2 %) caused by severe respiratory disease COVID-19 in second trimester. The other two death cases were pregnancy complicated with severe preeclampsia with hyperthyroid and preeclampsia with diabetes in pregnancy.  Perinatal outcomes were intrauterine fetal death (8.7%), stillbirth (2.2%), and severe asphyxia (2.2%).Conclusion: Although we obtain mostly maternal and perinatal outcomes in good outcomes, it is urgent to analyze potential high-risk maternal death with COVID 19.

Background: Premature rupture of membranes (PROM) is rupture of membranes amniotic membrane prior to the labor. PROM is associated with an increased incidence of preterm labor and infection.Aim: To compare maternal leukocyte count in premature rupture of membranes (PROM) and preterm premature rupture of membranes (PPROM)Methods: This cross-sectional design was conducted at Dr. Kariadi General Hospital Medical Center and Kartini General Hospital Jepara from September 2019 to January 2020. The study sample was pregnant women with premature rupture of membranes that came to Emergency Department. Samples were divided into two groups, PROM and PPROM. All samples were subjected to leukocyte count examination.Results: This study has a total of 40 samples, with 20 samples each. In PROM, 8 (40%) leukocytosis and 12 (60%) were normal, while in PPROM 7 (35%) leukocytosis and 13 (65%) were normal. There were no significant differences in maternal leukocyte levels in PROM and PPROM (p=0.229).Conclusion: There were no significant differences in maternal leukocyte levels in PROM and PPROM.

Background: Dysmenorrhea is the most common symptom of most menstrual complaints, and has a greater risk of causing disease than any other gynecological complaints. Dysmenorrhea can be accompanied by other symptoms such as sweating, tachycardia, nausea, vomiting, headache, diarrhea and tremors. Dysmenorrhea causes activity limitations which can affect productivity and quality of life of a woman.Objectives: Determine the effects of Zumba on primary dysmenorrhea among female students of the  Faculty of Medicine, Diponegoro University.Method: This study used an analytic observational study with a pretest-middletest-posttest design. A participants of 49 students were divided into 2 groups. The control group (K) was not given the Zumba intervention. Treatment group (P) was given 8-week intervention program with two 60’ sessions per week of Zumba. Data were collected before, during, and after Zumba intervention using a self-administrated dysmenorrhea questionnaire and VAS pain scale.Result: Based on the VAS pain scale and dysmenorrhea questionnaire, the mean value of the control group and treatment group was K: 2,02; 1,92; 2,06; P: 1,98; 1,98; 2,04. Statistical analysis using Friedman tests showed statistically not significant differences (p > 0,05).Conclusion: Zumba exercise did not have a significant difference in reducing dysmenorrhea pain levels.Keyword: Zumba exercise, exercise, primary dysmenorrhea, menstrual pain

Background: Preeclampsia (PE) is hypertension in pregnancy that currently occurs starting from the time of placentation and is 1 of the five leading causes of maternal death. The main cause of preeclampsia is the placenta, which is hypoxic, and the spiral artery remodeling fails. Hypoxia-inducible factor-1-alpha (HIF-1-A), a marker in the nucleus, is overexpressed during tissue hypoxia. Pravastatin has a pleiotropic effect as the synthesis of nitric oxide (NO), a strong vasodilator to correct hypoxia. This study aims to explore the potential of pravastatin against functional abnormalities or placental hypoxia through in vivo HIF-1-A expression. Methods: This study is an experimental study using female Wistar rats (Rattus norvegicus) induced by preeclampsia. Assessment of HIF-1-A expression was carried out by immunohistochemistry. Data analysis was performed using SPSS, and then univariate and bivariate tests were performed. Results: Administration of pravastatin at a dose of 10 mg/kg BW showed the most optimal potential in reducing the expression of HIF-1-A protein, indicating tissue hypoxia. Pravastatin doses of 2.5 mg/kg BW and 5 mg/kg BW also could reduce HIF-1-A protein expression better than the K+ group who were not given pravastatin. Conclusion: Pravastatin can reduce the expression of HIF-1-A protein in pre-eclamptic rats, which indicates the potential of pravastatin to reduce the incidence of preeclampsia.