This study aims to analyze the effect of Job Satisfaction, Work-Life Balance on the Job Performance of Female Nurses at Klungkung General Hospital. The sample in this study were all female nurses totaling 206 female nurses at the Klungkung General Hospital. Filling out the questionnaire was done using a google form due to the Covid-19 pandemic and it was more effective and efficient. Determination of the sample in this study is using non-probability sampling technique with saturated sampling, namely the technique of determining the sample when all members of the population are used as samples. The saturated sample can also be referred to as a census because all members of the female nurse population are sampled. Data were analyzed using Path Analysis on SPSS Program. The results show that Work-life balance has a positive and significant effect on the performance of female nurses; Work-life balance has a positive and significant effect on job satisfaction of female nurses; Job satisfaction has a positive and significant effect on nurse performance; and job satisfaction significantly mediate the relationship between the work-life balance on the performance of female nurses.