Introduction: Surgical procedure were often done with incicion involved which could result in the damage of the tissues, stimulating the process of healing. Healing process is dynamic and consists of several phases; inflammation, proliferation, and maturation. Fibroblast cell started to flourish in the proliferation phase. One of the herbal plants that played an important role in healing process is Aloe vera. The nutrition of Aloe vera helped the cells regeneration process, which can be used as anti-bacteria, anti-fungus, and anti-inflammation. This research aimed to identify the effectivity of Aloe vera extract to the number of fibroblast cells in the incised healing process of Cavia cobaya. Methods: This research used 9 adult male Cavia cobaya. Two incised wounds were made vertically in the back of each Cavia cobaya. The first incised wound then was treated with 75% aloe vera extract and the sample was used as test group. Meanwhile the second wound was treated with aquades (distilled water) as control group. The treatment was given for 4 days and in the fifth day all subjects were decapitated and were brought to histology examination to count the number of fibroblast cell. The whole process was then analysed by independent t-test. Result: There was significant difference in the number of fibroblast cell of test group and control group (p<0.05). Conclusion: It can be concluded that 75% of aloe vera extract can increase the number of fibroblast cell in the healing process of Cavia cobaya incised wound.

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An abscess is a typical infection caused by Staphylococcus aureus bacteria. Resistance of bacteria occurs due to improper antibiotics dosage, inaccurate diagnosis, and improper bacterial causes. Rhizome Bangle contains saponins, flavonoids and essential oils, alkaloids, tannins, and glycosides that have antibacterial. The purpose of this study is to determine the inhibitory effect of rhizome Bangle extract (Zingiber purpureum Roxb.) on the growth of Staphylococcus aureus bacteria in Vitro. The study was an experimental laboratory study with group design post-test in vitro. The method used as the antibacterial test was the Kirby Bauer diffusion method. Concentration of rhizome Bangle extract were 8%, 16%, 32%, and negative control of ethanol and positive control of chlorhexidine 0,2%. The culture medium used Mueller Hinton agar (MHA). Data analyzed by Krusskal wallis (p <0.05). The result of this study shows Rhizome Bangle extract 32% concentration inhibit Staphylococcus aureus bacteria growth significant with p= 0.001. The conclusion is that rhizome Bangle extract (Zingiber purpureum Roxb.) inhibits the growth of Staphylococcus aureus bacteria at 32% concentration.

Tooth extraction is a common practice in dentistry. Tooth extraction will cause injuries that need healing before they can return to the physiological state of the oral cavity. Snail mucus contains beta agglutinin (antibodies) in plasma (serum), achasin protein, glycoconjugate and sulfate levels which can accelerate wound healing by increasing the mobilization of macrophage cells on day 5 after tooth extraction. The purpose of this study was to determine the effectiveness of snail mucus on the number of macrophage cells in wound healing after extraction of guinea pigs. The research method used was pure experimental research using 32 guinea pigs as samples. Guinea pigs were divided into 2 (two) groups: the control group was given 2% CMC-Na gel and the treatment group was given snail mucus after having been extracted. Calculation of the number of macrophages is done on the 5th day. The results showed the mean number of macrophage cells in the control group was 13.06 cells, and the treatment group was 17.44 cells. After being analyzed using the Independent t-test with significance ρ <0.05, it was found that there were significant differences in the number of macrophage cells in the test group and the control group. From this study it can be concluded that snail mucus is effective in increasing the number of macrophage cells in the process of wound healing after tooth extraction.

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