: Cardiovascular diseases are the most common cause of death worldwide, with cardiovascular medications being amongst the most common medications prescribed. These medications have diverse effects on the heart, vascular system as well as other tissues and organ systems. The extra cardiovascular effects have been found to be of use in the treatment of non-cardiovascular diseases and pathologies. Minoxidil is used to manage systemic hypertension with its well-known side effect of hirsutism used to treat alopecia and baldness. Sildenafil was originally investigated as a treatment option for systemic hypertension however its side effect of penile erection led to it be widely used for erectile dysfunction. Alpha-1 blockers such as terazosin are indicated to treat systemic hypertension but are more commonly used for benign prostatic hyperplasia and post-traumatic stress disorder. Beta blockers are the mainstay treatment for congestive heart failure and systemic hypertension but have found use to help in patients with intention tremors as well as prophylaxis of migraines. Similarly, calcium channel blockers are indicated in medical expulsion therapy for ureteric calculi in addition to their cardiovascular indications. Thiazides are commonly used for treating systemic hypertension and as diuretics. Thiazides can cause hypocalciuria and hypercalcemia. This side effect has led to thiazides being used to treat idiopathic hypercalciuria and associated nephrolithiasis. Spironolactone is commonly utilized in treating heart failure and as a diuretic for edema. It’s well described anti-androgen side effects have been used for acne vulgaris and hirsutism in polycystic ovarian syndrome. This review article discusses how the various extra-cardiovascular effects of commonly used cardiovascular medications are put to use in managing non-cardiovascular conditions.

Safed-koh Trend is located in D.G.Khan district, Punjab province, Pakistan. It is a north south trending fold belt that lies in Eastern Part of Sulaiman Fold Belt. Seismic data correlation is done with the help of well data, Formations' tops, Synthetics and general stratigraphy of the area. The Structural and Stratigraphical interpretation shows subsurface variations. Depth model shows Dhodak, Rodho, Afiband and Zindapir anticlines, the four culminations of Safed-Koh Trend without marking the faults. Dhodak is a northern lower most culmination. Zindapir is the most uplifted one and broader structure comparatively that lies at southern edge. 3D subsurface Time & Depth models of Rubbly Limestone, Dunghan Formation, Pab Sandstone, Lower Goru Formation and Chiltan Limestone map Dhodak anticlinal structure with reverse faults at its flanks. Dunghan, Ranikot, Pab and Chiltan Formations in this area have already proved to be good quality reservoirs for gas. Pab Sandstone and sands of Lower Goru Formation of Cretaceous and Chilton Limestone of Jurassic age could also be the important reservoirs in unexplored area. Rock Physics analysis of Chilton Formation confirms the hydrocarbon potential.

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