The work is aimed at solving the problem of colleges and universities to expand the enrollment scale and optimize the management strategy. Based on grid management theory, wireless communication network, NET framework technology, and the browser/server (B/S) framework, a grid security management system is presented. Grid knowledge is explained, wireless communication network address calculation and analysis are mentioned, and NET framework technology and analysis of B/S framework technology optimized by C/S (client/server) framework technology are discussed. The grid management system is built on this foundation and applied to university management. Two questionnaires are designed to explore the grid management of students and faculty. Students believe that the system can effectively solve their management problems, and teachers and workers believe that the system can optimize their work. These results show that the grid management system can be applied to the management of colleges and universities, which provides some ideas for optimizing the management strategy of colleges and universities.