No abstract

Correlation of clinical features with hypersensitive C-reactive protein (hs-CRP) in patients with treatment-resistant depression (TRD) was investigated. The severity of disease in 103 TRD patients and 103 non-TRD patients was evaluated using the Hamilton Depression Scale (HAMD)-17. The levels of hs-CRP in both groups were detected via immunofluorescence. Clinical features and differences in hs-CRP before and after treatment in both groups were analyzed, and correlation of baseline hs-CRP level with clinical features of TRD patients was also analyzed. Moreover, the relationship between hs-CRP and occurrence of TRD was analyzed using logistic regression analysis, and the diagnostic value of hs-CRP in TRD was evaluated using the receiver operating characteristic (ROC) curve. The onset age in the TRD group was lower than that in the non-TRD group, the education in the TRD group was shorter than that in the non-TRD group, the total course of disease in the TRD group was longer than that in the non-TRD group, and both baseline and post-treatment hs-CRP level in the TRD group (12.05±5.79 and 9.02±3.71 mg/l) were higher than those in the non-TRD group (7.85±2.85 and 6.10±2.74 mg/l) (p<0.05). The HAMD score (r=0.338, p=0.031), anxiety/somatization factor score (r=0.465, p=0.015) and sleep disorder (r=0.387, p=0.029) of TRD patients were positively correlated with the hs-CRP level, but the onset age (r=−0.59, p=0.009) was negatively correlated with the hs-CRP level. Logistic regression analysis revealed that the baseline hs-CRP was included into the TRD regression equation [odds ratio (OR) =2.834, 95% confidence interval (CI) =1.723–4.886], and the area under the ROC curve was 0.893 (p<0.05, 95% CI=0.852–0.933). In the TRD group, the course of TRD in patients was longer, the onset of disease was earlier and the educational level was lower than that in the non-TRD group. Therefore, the level of hs-CRP can serve as a reference for the diagnosis of TRD.

Purpose: To investigate the antidepressant effect of Cyperus rotundus L. extract (CRLE) in rats.

Background The aim of this study was to evaluate the reliability and validity of the Chinese version of the Cognitive Distortions Questionnaire (CD-Quest) among Chinese college students. Material/Methods A total of 460 college students from Jining were recruited in the study. Sample 1, including 239 college students, was tested for item analysis and exploratory factor analysis. Sample 2, including 221 college students, was tested for confirmatory factor analysis and criterion validity. The criterion validity was tested using the Negative Automatic Thoughts questionnaire (ATQ) and Dysfunctional Attitudes Scale (DAS). Test-retest reliability was evaluated in 40 college students from sample 1 with 4 weeks interval. Results The corrected item-total correction (ITC) ranged from 0.675 (emotional reasoning) to 0.829 (unfair comparison). Exploratory factor analysis revealed the variance of the CD-Quest items was unidimensional, and it explained 55.261% of the data variance. Confirmatory factor analysis indicated all regression coefficients were higher than 0.4. The criterion validity was excellent, as shown by the relationships among CD-Quest, DAS, and ATQ ( r =0.447, 0.566, respectively). Cronbach’s α coefficient was 0.941 and the test-retest reliability was 0.928. Conclusions The Chinese version of CD-Quest had good reliability and validity, suggesting it is a reliable tool to evaluate cognitive distortion of Chinese college students.