BACKGROUND Background: Cardiac hypertrophy induced by pressure overload is one of the important causes of heart failure and sudden cardiac death. At present, there are few studies on the outcome of left ventricular hypertrophy and left ventricular function after complete pressure load removal. OBJECTIVE Objective: The objective is to better simulate the changes of left ventricular structure and function during the process of left ventricular pressure overload and de-loading, and to explore the application of echocardiography in it. METHODS Methods: In this study, healthy male BALB/c mice are used as research objects to establish ascending aorta constriction model, to carry out echocardiographic and hemodynamic examinations, to establish ascending aorta de-constriction model in mice, and to carry out echocardiographic and hemodynamic examinations. RESULTS Results: Compared with the sham operation group, LVESD, LVEDD, IVS, and LVPW in the constriction operation group were significantly increased (P < 0.05); LVESD, LVEDD, IVS, and LVPW in the early and late constriction groups were significantly decreased (P < 0.05), and the degree of decrease in the early group was greater than that in the late group (P < 0.05); compared with the sham operation group, LVDP in the constriction operation group increased significantly at 9 and 15 weeks after operation; LVSP of 15 weeks after operation decreased to a certain extent but was higher than that of sham operation group (P < 0.05); +dp/dtmax of 3 weeks, 9 weeks, and 15 weeks after operation decreased significantly (P < 0.05); -dp/dtmax of 3 weeks, 9 weeks and 15 weeks after operation decreased significantly (P < 0.05). CONCLUSIONS Conclusions: In this study, ascending aorta coarctation model and descending aorta coarctation model are successfully established, which verifies the value of echocardiography information data monitoring in treatment of left ventricular circulation disorders and the evaluation of surgical treatment. CLINICALTRIAL

Background Cardiac hypertrophy induced by pressure overload is one of the important causes of heart failure and sudden cardiac death. At present, there are few studies on the outcome of left ventricular hypertrophy and left ventricular function after complete pressure load removal. Objective This study aims to better simulate the changes of left ventricular structure and function during the process of left ventricular pressure overload and deloading, and to explore the application of echocardiography in it. Methods In this study, healthy male (BALB/C) mice were used as research objects to establish an ascending aorta constriction model, to carry out echocardiographic and hemodynamic examinations, to establish an ascending aorta deconstriction model in mice, and to carry out echocardiographic and hemodynamic examinations. Results Compared with the sham operation group, the left ventricular end-systolic diameter (LVESD), left ventricular end-diastolic diameter (LVEDD), interventricular septal (IVS), and left ventricular posterior wall (LVPW) in the constriction operation group were significantly increased (P=.02, P=.02, P=.02, and P=.02, respectively). LVESD, LVEDD, IVS, and LVPW in the early and late constriction groups were significantly decreased, and the degree of decrease in the early group was greater than that in the late group; compared with the sham operation group, left ventricular diastolic pressure in the constriction operation group increased significantly at 9 and 15 weeks after operation (P=.03). Left ventricular systolic pressure at 15 weeks after operation decreased to a certain extent but was higher than that of the sham operation group (P=.02). The maximal rate of the increase of left ventricular pressure at 3 weeks, 9 weeks, and 15 weeks after operation decreased significantly (P=.03, P=.02, and P=.02, respectively). Conclusions In this study, the ascending aorta coarctation model and descending aorta coarctation model were successfully established, which verifies the value of echocardiography information data monitoring in the treatment of left ventricular circulation disorders and the evaluation of surgical treatment.