The triboelectric nanogenerator (TENG) is an emerging technology for ambient mechanical energy harvesting, which provides a possibility to realize wild environment monitoring by self‐powered sensing systems. However, TENGs are limited in some practical applications as a result of their low output performance (low charge density) and mechanical durability (material abrasion). Herein, an ultrarobust and high‐performance rotational TENG enabled by automatic mode switching (contact mode at low speed and noncontact at high speed) and charge excitation is proposed. It displays excellent stability, maintaining 94% electrical output after 72 000 cycles, much higher than that of the normal contact‐mode TENG (30%). Due to its high electrical stability and large electrical output, this TENG powers 944 green light‐emitting diodes to brightness in series. Furthermore, by harvesting water‐flow energy, various commercial capacitors can be charged quickly, and a self‐powered fire alarm and self‐powered temperature and humidity detection are realized. This work provides an ideal scheme for enhancing the mechanical durability, broadening the range of working frequency, and improving the electrical output of TENGs. In addition, the high‐performance hydrodynamic TENG demonstrated in this work will have great applications for Internet of Things in remote areas.

Available studies demonstrate that receptor-type tyrosine-protein phosphatase zeta (PTPRZ1) is expressed in different tumor tissues, and functions in cell proliferation, cell adhesion and migration, epithelial-to-mesenchymal transition, cancer stem cells and treatment resistance by interacting with or binding to several molecules. These included pleiotrophin (PTN), midkine, interleukin-34, β-catenin, VEGF, NF-κB, HIF-2, PSD-95, MAGI-3, contactin and ErbB4. PTPRZ1 was involved in survival signaling and could predict the prognosis of several tumors. This review discusses: the current knowledge about PTPRZ1, its expression, co-receptors, ligands, functions, signaling pathway, prognostic values and therapeutic agents that target PTPRZ1.

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Fire warning and monitoring are very important for public safety and environmental protection. However, most of the proposed wind energy conversion devices based on triboelectric nanogenerator (TENG) only work for unidirectional and high-speed wind and face the challenge of fatigue damage and even failure caused by cyclic stress. Moreover, TENG guided by the theory of fluid dynamics needs further exploration. Herein, a flowinduced vibration effect based TENG (F-TENG) for continuously capturing and monitoring multidirectional breeze (1.8-4.3 m s −1 ) is developed to build a self-powered intelligent fire detection system (SIFDS). A dynamic model is proposed to study the intrinsic interaction between the electrical properties of F-TENG and wind. Since the model optimized F-TENG is more adaptable to wind characteristics, it delivers better performance and higher durability compared with previous studies. Relying on the dynamic model and combining the relationship between F-TENG's electrical output and wind characteristics, a self-powered visual wind sensing system is obtained. F-TENG successfully drives some electronic devices to monitor environmental information, which is expected to provide data for SIFDS to reduce fire hazards. This study can provide an in-depth understanding of the electromechanical conversion mechanism and large-scale capture and utilization of breeze energy.

All-trans retinoic acid (ATRA) regulates skin cell proliferation and differentiation. ATRA is widely used in the treatment of skin diseases, but results in irritation, dryness and peeling, possibly due to an impaired skin barrier, although the exact mechanisms are unclear. The present study established an ATRA-associated dermatitis mouse model (n=32) in order to examine the molecular mechanisms of skin barrier impairment by ATRA. Changes in epidermal morphology and structure were observed using histological examination and transmission electron microscopy (TEM). Gene expression was analyzed by microarray chip assay. Histology and TEM demonstrated pronounced epidermal hyperproliferation and parakeratosis upon ATRA application. The stratum corneum layer displayed abnormal lipid droplets and cell-cell junctions, suggesting alterations in lipid metabolism and dysfunctional cell junctions. Gene expression profiling revealed that factors associated with epidermal barrier function were differentially expressed by ATRA, including those associated with tight junctions (TJs), cornified envelopes, lipids, proteases, protease inhibitors and transcription factors. In the mouse epidermis, Claudin-1 and -4 are proteins involved in TJs and have key roles in epidermal barrier function. ATRA reduced the expression and altered the localization of Claudin-1 in HaCaT immortalized keratinocytes and the mouse epidermis, which likely leads to the disruption of the epidermal barrier. By contrast, Claudin-4 was upregulated in HaCaT cells and the mouse epidermis following treatment with ATRA. In conclusion, ATRA exerts a dual effect on epidermal barrier genes: It downregulates the expression of Claudin-1 and upregulates the expression of Claudin-4. Claudin-4 upregulation may be a compensatory response for the disrupted barrier function caused by Claudin-1 downregulation.