SF had favorable effects on body weight, BMI, and fasting LDL-C levels in overweight and obese adults. These effects may be beneficial in antiobesity and the improvement of hyperlipidemia and hypertension (ClinicalTrials.gov registration number-NCT01802840).

Skin cutaneous melanoma can be robustly divided into three subtypes by SNFCC. Compared with the TCGA classification derived from gene expression, the subtypes we presented share concordance, but new traits are excavated. Such a genomic classification offers insights to further personalize therapeutic decision-making and melanoma management.

Ridge slopes often occur in highway or railway engineering. The initial stress distribution of a ridge slope is important for the original slope and an excavation slope. In this paper, a wire-frame model of ridge slope was established. Numerical simulations on the 3D stability analysis were performed using the strength reduction method based on unified strength theory. The influences of ridgeline dip angle α, flank slope angle β, and slope height H on the deformation and failure mode of ridgeline slopes were analyzed. When α was small, cracking failure easily occurred at the front edge of the ridge slope and the area near the ridge line. When α was large, shear failure was prone to occur at the trailing edge of the ridge slope. Under the same reduction coefficient, the larger the flank slope angle β, the larger the slope displacement of the ridge. The plastic zone gradually concentrated near the ridge. When H was small, the displacement mainly occurred at the trailing edge of the slope, and the slopes were generally prone to cracking damage at the trailing edge. The front edge of the slope experienced a large displacement when the height of the ridge slope increased. The bottom of the flank slope was also displaced, and a plastic zone was observed at the foot of the slope. When the excavation slope ratio of the ridge slope was small, the plastic zone was mainly located on the side slope. When the excavation rate increased, the plastic zone appeared on the excavation slope surface, and its stability decreased significantly.

Objective: Uterine carcinosarcomas (UCSs) are aggressive rare tumors recognized as malignancies composed of metaplastic transformation of epithelial elements. Nay no comprehensive molecular classification has been applied to UCS to guide targeted therapies so far, which motivated us to subtyping UCS by aggregating multiple genomic platform data. Methods: We classified UCS into three distinct subtypes with different clinicopathologic and molecular characterization by using similarity network fusion under consensus clustering framework (SNFCC +) to aggregate four genomic data platforms of 55 UCS patients. Differences across subtypes were extracted by functional enrichment, gene mutations and clinical features. Subtypes were further distinguished by putative biomarkers. We also determined associations between individual oncogenes and chemotherapeutics to discuss subtype-specific drug sensitivity. Results: Functional enrichment analysis of the subtype-specific differential expression genes endowed three subtypes new designation: Myo, Cell and Hormone. Mutations in PTEN, PIK3CA, ARID1A and PPP2R1A altered across subtypes. The epithelial-to-mesenchymal transition (EMT) score distinguished Myo from another two subtypes whereby a high EMT scores prevalently existed and each case was judged as M (mesenchymal) phenotype in Myo subtype. Through the drug sensitivity analysis, we found that the response totinib drugs is quite different across subtypes according to expression level. Additionally, different subtypes' response to broad-spectrum anti-cancer drug paclitaxel may be also different. Conclusions: In this study, we identified three distinct molecular subtypes of UCS with different features. Subtypes were also revealed to have different sensitivity to existing chemotherapy drugs, which may support in-depth study of subtype-specific dosing regimens.

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