Selective gene expression in tumors via responsive dissociation of polyplexes triggered by intracellular signals is demonstrated. An esterase-responsive charge-reversal polymer mediates selective gene expression in the cancer cells high in esterases over fibroblasts low in esterase activity. Its gene therapy with the TRAIL suicide gene effectively induces apoptosis of HeLa cells but does not activate fibroblasts to secrete WNT16B, enabling potent cancer gene therapy with few side effects.

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This paper presents a multi-agent constrained reinforcement learning (RL) policy gradient method for optimal power management of networked microgrids (MGs) in distribution systems. While conventional RL algorithms are black box decision models that could fail to satisfy grid operational constraints, our proposed RL technique is constrained by AC power flow equations and other operational limits. Accordingly, the training process employs the gradient information of the power management problem constraints to ensure that the optimal control policy functions generate feasible decisions. Furthermore, we have proposed a distributed primal-dual consensus-based training approach for the RL solver to maintain the privacy of MGs' control policies. After training, the learned optimal policy functions can be safely used by the MGs to dispatch their local resources, without the need to solve a complex optimization problem from scratch. Numerical experiments have been devised to verify the performance of the proposed method.

This paper presents an approximate Reinforcement Learning (RL) methodology for bi-level power management of networked Microgrids (MG) in electric distribution systems. In practice, the cooperative agent can have limited or no knowledge of the MG asset behavior and detailed models behind the Point of Common Coupling (PCC). This makes the distribution systems unobservable and impedes conventional optimization solutions for the constrained MG power management problem. To tackle this challenge, we have proposed a bi-level RL framework in a price-based environment. At the higher level, a cooperative agent performs function approximation to predict the behavior of entities under incomplete information of MG parametric models; while at the lower level, each MG provides powerflow-constrained optimal response to price signals. The function approximation scheme is then used within an adaptive RL framework to optimize the price signal as the system load and solar generation change over time. Numerical experiments have verified that, compared to previous works in the literature, the proposed privacy-preserving learning model has better adaptability and enhanced computational speed.

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