Introduction Obesity is a critical pathogenic factor of hypertension and hyperlipidemia in metabolic syndrome and an independent risk factor of cardiovascular disease leading to low cardiorespiratory endurance. Objective Explore the changes in cardiorespiratory endurance adaptation on obese subjects caused by aerobic exercise. Methods A cardiorespiratory exercise model was proposed for obese people under different optimizations based on critical variables and cluster analysis. This model analyzes the relationship between exercise and cardiorespiratory endurance in obese people, extracts the cardiorespiratory endurance index characteristics of obese people under different exercise levels, and clusters their different index characteristics. Results The difference between the heart rate of the proposed model and the actual heart rate is 0.11, the difference between the heart rate of the model and the actual heart rate is 4.28, and the difference between the heart rate of the model and the actual heart rate is 2.84, and the accuracy of the proposed model is the highest. Conclusion The model proposed in this paper can accurately analyze the effects of different aerobic exercise frequencies on cardiorespiratory endurance. Evidence Level II; Therapeutic Studies - Investigating the result.