This paper proposes a solution to the simulated deformation of guidewires when they come in contact with the blood vessel in an interventional surgery simulation training system. Starting from the principle of minimum energy, the guidewire is evenly dispersed into a rigid light bar articulation model. A sequential quadratic programming (SQP) algorithm is used to nonlinearly optimize the deflection angle of each light bar. When the elastic potential energy of the guidewire reaches a minimum, we can get the guidewire deformation we want to solve. The method proposed in this paper avoids necessity of delving into contact deformation caused by the contact force between the guidewire and the blood vessel wall, while solving the problem of the deformation of the guidewire due to the pose of the contact points. We use an ABAQUS (finite element software) simulation to verify that this solution has a theoretical simulation accuracy of 5.11%, and the designed experiments prove that the actual simulation accuracy is about 11%. Moreover, we also simulated the bending stress state of the guidewire by using the deflection angle of each bar. In addition, in order to achieve the most suitable simulation results, we discuss the discrete density of the guidewire model from the perspective of algorithm time consumption and simulation accuracy.