Objective: Surgical site infections (SSI) is a serious complication of surgery. Perioperative antibacterial prophylaxis is one of the most effective methods to prevent SSI. The aim of this study was to evaluate the effect of interventions on perioperative antibacterial prophylaxis in neurosurgery. Method: We intervened and assessed the perioperative antibacterial prophylaxis from adult patients with a neurological surgery in the First Affiliated Hospital of Jinan University (Guangzhou, China) between May 2014 and December 2014. A total of 279 neurosurgical cases were chosen among which 145 cases were before intervention and 134 after intervention. This study discussed the indications, selection of varieties, timing of the first dose, and application time of antibacterial drugs before and after intervention. Results: Investigation and analysis were performed in the perioperative antibacterial prophylaxis. Compared with the pre-intervention phase, rationalities of perioperative antibiotics prophylaxis in the post-intervention phase were significantly increased. The rational drug selection and the rational timing of using antibacterial after intervention were significantly increased. In addition, the average duration of antibiotic prophylaxis in the post-intervention phase was significantly shorter than the pre-intervention phase. Conclusion: The intervention of perioperative antibiotics prophylaxis was effective and feasible. It contributed to promoting the rational use of perioperative antibiotics prophylaxis in neurosurgery.

Objective: To assess the effect of orthopedic perioperative antibiotic prophylaxis intervention by clinical pharmacist.Methods: 1467 hospitalized patients in department of orthopedics with perioperative records in eight months in 2019 were chosen. 597 surgical cases before intervention were sampled as the control group, and 870 surgical records were sampled as intervention group. Investigation and analysis were performed in orthopedic perioperative prophylactic antibiotics. Results: Compared with the control group, the intervention group showed increased rationalities and decreased irrationalities in perioperative antibiotic prophylaxis. The unreasonable external use of teicoplanin was significantly decreased, and the postoperative prophylaxis duration was significantly shortened. There were no significant difference in the timing of perioperative antibiotic prophylaxis between two groups. Conclusions: After interventions for the preventive use of antibacterial drugs in orthopedic perioperative period, the rational use of antibacterial drugs has been significantly improved, the irrational use of drugs has been improved, and the effect of drug treatment has been improved. However, there is still a gap between the rational use of antibacterial drugs. Further strengthen supervision and management.