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PurposeThe purpose of this study was to evaluate the diagnostic accuracy of artificial intelligence (AI) models with magnetic resonance imaging(MRI) in predicting pathological complete response(pCR) to neoadjuvant chemoradiotherapy (nCRT) in patients with rectal cancer. Furthermore, assessed the methodological quality of the models.MethodsWe searched PubMed, Embase, Cochrane Library, and Web of science for studies published before 21 June 2022, without any language restrictions. The Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) and Radiomics Quality Score (RQS) tools were used to assess the methodological quality of the included studies. We calculated pooled sensitivity and specificity using random-effects models, I2 values were used to measure heterogeneity, and subgroup analyses to explore potential sources of heterogeneity.ResultsWe selected 21 papers for inclusion in the meta-analysis from 1562 retrieved publications, with a total of 1873 people in the validation groups. The meta-analysis showed that AI models based on MRI predicted pCR to nCRT in patients with rectal cancer: a pooled area under the curve (AUC) 0.91 (95% CI, 0.88-0.93), sensitivity of 0.82(95% CI,0.71-0.90), pooled specificity 0.86(95% CI,0.80-0.91). In the subgroup analysis, the pooled AUC of the deep learning(DL) model was 0.97, the pooled AUC of the radiomics model was 0.85; the pooled AUC of the combined model with clinical factors was 0.92, and the pooled AUC of the radiomics model alone was 0.87. The mean RQS score of the included studies was 10.95, accounting for 30.4% of the total score.ConclusionsRadiomics is a promising noninvasive method with high value in predicting pathological response to nCRT in patients with rectal cancer. DL models have higher predictive accuracy than radiomics models, and combined models incorporating clinical factors have higher diagnostic accuracy than radiomics models alone. In the future, prospective, large-scale, multicenter investigations using radiomics approaches will strengthen the diagnostic power of pCR.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42021285630.

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IntroductionIn recent years, the concept of living systematic review (LSR) has attracted the attention of many scholars and institutions. A growing number of studies have been conducted based on LSR methodology, but their focus direction is unclear. The objective of this study was to provide a comprehensive review of existing LSR-related studies and to analyse their whole picture and future trends with bibliometrics.MethodsA comprehensive search strategy was used to construct a representative dataset of LSRs up to October 2021. GraphPad V.8.2.1 and Mindmaster Pro presented the basic information of the included studies and the timeline of LSR development, respectively. The author and country cooperation network, hotspot distribution clustering, historical citation network and future development trend prediction related to LSR were visualised by VOSviewer V.1.6.16 and R-Studio V.1.4.ResultsA total of 213 studies were eventually included. The concept of LSR was first proposed in 2014, and the number of studies has proliferated since 2020. There was a closer collaboration between author teams and more frequent LSR research development and collaboration in Europe, North America and Australia. Numerous LSR studies have been published in high-impact journals. COVID-19 is the predominant disease of concern at this stage, and the rehabilitation of its patients and virological studies are possible directions of research in LSR for a long time to come. A review of existing studies found that more than half of the LSR series had not yet been updated and that the method needed to be more standardised in practice.ConclusionAlthough LSR has a relatively short history, it has received much attention and currently has a high overall acceptance. The LSR methodology was further practised in COVID-19, and we look forward to seeing it applied in more areas.

24, 2'/exp OR '25-hydroxyvitamin d 2' OR '4-aminobenzoic acid'/exp OR '4-aminobenzoic acid' OR 'acetylcarnitine' OR 'acetylcarnitine'/exp OR acetylcarnitine OR 'alphatocopherol'/exp OR 'alpha-tocopherol' OR 'aminobenzoic acids'/exp OR 'aminobenzoic acids' OR 'ascorbic acid'/exp OR 'ascorbic acid' OR 'beta carotene'/exp OR 'beta carotene' OR 'beta-tocopherol'/exp OR 'beta-tocopherol' OR 'be-ta-tocopherol' OR 'biotin' OR 'biotin'/exp OR biotin OR 'boron' OR 'boron'/exp OR boron OR 'cadmium' OR 'cadmium'/exp OR cadmium OR 'calcifediol' OR 'calcifediol'/exp OR calcifediol OR 'calcitriol' OR 'calcitriol'/exp OR calcitriol OR 'carnitine' OR 'carnitine'/exp OR carnitine OR 'cholecalciferol' OR 'cholecalciferol'/exp OR cholecalciferol OR 'chromium' OR 'chromium'/exp OR chromium OR 'cobalt' OR 'cobalt'/exp OR cobalt OR 'cobamides' OR 'cobamides'/exp OR cobamides OR 'cod liver oil'/exp OR 'cod liver oil' OR 'copper' OR 'copper'/exp OR copper OR 'dehydroascorbic acid'/exp OR 'dehydroascorbic acid' OR 'dihydrotachysterol' OR 'dihydrotachysterol'/exp OR dihydrotachysterol OR 'dihydroxycholecalciferols' OR 'dihydroxycholecalciferols'/exp OR dihydroxycholecalciferols OR 'ergocalciferols' OR 'ergocalciferols'/exp OR ergocalciferols OR 'flavin mononucleotide'/exp OR 'flavin mononucleotide' OR 'folic acid'/exp OR 'folic acid' OR 'formyltetrahydrofolates'/exp OR 'formyltetrahydrofolates' OR 'fursultiamin' OR 'fursultiamin'/exp OR fursultiamin OR 'gamma-tocopherol'/exp OR 'gamma-tocopherol' OR 'hydroxocobalamin' OR 'hydroxocobalamin'/exp OR hydroxocobalamin OR 'hydroxycholecalciferols' OR 'hydroxycholecalciferols'/exp OR hydroxycholecalciferols OR 'inositol' OR 'inositol'/exp OR inositol OR 'iodine' OR 'iodine'/exp OR iodine OR 'iron' OR 'iron'/exp OR iron OR 'leucovorin' OR 'leucovorin'/exp OR leucovorin OR 'manganese' OR 'manganese'/exp OR manganese OR 'magnesium' OR 'magnesium'/exp OR magnesium OR 'molybdenum' OR 'molybdenum'/exp OR molybdenum OR 'niacin' OR 'niacin'/exp OR niacin OR 'niacinamide' OR 'niacinamide'/exp OR niacinamide OR 'nickel' OR 'nickel'/exp OR nickel OR 'nicorandil' OR 'nicorandil'/exp OR nicorandil OR 'nicotinic acids'/exp OR 'nicotinic acids' OR 'palmitoylcarnitine' OR 'palmitoylcarnitine'/exp OR palmitoylcarnitine OR 'pantothenic acid'/exp OR 'pantothenic acid' OR 'pteroylpolyglutamic acids'/exp OR 'pteroylpolyglutamic acids' OR 'pyridoxal' OR 'pyridoxal'/exp OR pyridoxal OR 'pyridoxal phosphate'/exp OR 'pyridoxal phosphate' OR 'pyridoxamine' OR 'pyridoxamine'/exp OR pyridoxamine OR 'pyridoxine' OR 'pyridoxine'/exp OR pyridoxine OR 'riboflavin' OR 'riboflavin'/exp OR riboflavin OR 'selenium' OR 'selenium'/exp OR selenium OR 'silicon' OR 'silicon'/exp OR silicon OR 'tetrahydrofolates' OR 'tetrahydrofolates'/exp OR tetrahydrofolates OR 'thiamine' OR 'thiamine'/exp OR thiamine OR 'thiamine monophosphate'/exp OR 'thiamine monophosphate' OR 'thiamine pyrophosphate'/exp OR 'thiamine pyrophosphate' OR 'thiamine triphosphate'/exp OR 'thiamine triphosphate' OR 'thioctic acid'/exp OR 'thioctic acid' OR 'tin' OR 'tin...