Objective To investigate the effect of the FOCUS program on the self-efficacy of caregivers of patients with advanced lung cancer.Method In this experimental study, a total of 108 caregivers for patients admitted to a tertiary comprehensive hospital from April 2019 to December 2019 were recruited based on inclusion and exclusion criteria. Based on their admission dates, the caregivers were divided into a control group (54 cases), which only completed routine measures, and a test group (54 cases), which completed the FOCUS Program in addition to routine measures. At the 4th week of the intervention, general self-efficacy, caregiving burden, coping styles and mood states were compared between the control group and the test group.Results The general self-efficacy scale, caregiver burden scale, simple coping style scale and mood state scale were compared between the two groups at the 4th week of the intervention and at 8 weeks after the intervention.After the intervention, the self-efficacy scores of the test group (24.37±4.375) were higher than those of the control group (17.50±3.479), and the difference was statistically significant (t=-9.032, P<0.05); the caregiving burden scores of the test group (41.65± 2.735) were lower than those of the control group (47.33±7.066), and the difference was statistically significant (t=5.514, P<0.05); the coping style scores of the experimental group (33.20±5.533) were significantly higher than those of the control group (28.76±3.420) (t=-5.021, P<0.05); the mood state scale scores of the test group (106.17±12.400) were lower than those of the control group (127.65±11.754), and the difference was statistically significant (t=9.239, P<0.05).The results showed that the intergroup comparisons, group comparisons and interactions were statistically significant (P<0.05).Conclusion The FOCUS Program can effectively improve the self-efficacy of caregivers, reduce their caregiving burden improve their coping styles and enhance their mood states.