Carbon-carbon activation | Transition-metal | Asymmetric catalysis | Asymmetric synthesis | Ring-opening reaction Catalytic asymmetric transformations involving carbon-carbon bond cleavages open intriguing strategies for the synthesis of chiral complex molecules. The transient organometallic species mainly generate from the oxidative addition of cyclic compounds with low valence metals or from β-carbon elimination of tert-alkoxyl metals. This overview covers the recent advances in transition-metal-catalyzed carbon-carbon bond activation in asymmetric synthesis. Xiufen Bi (left) was born in Anhui, China. She obtained her bachelor degree from Anhui Normal University in 2017. Then she turned to University of Science and Technology of China (USTC) to pursue her PhD degree of organic chemistry under the supervision of Professor Gu. Qiuchi Zhang (middle) was born in Sichuan, China. He received his bachelor degree from USTC in 2014. Then he turned to Nanyang Technological University for his doctoral studies and received PhD degree in 2019 under the supervision of Prof. Tech-Peng Loh. He is currently a post-doctor in Prof. Gu's group at USTC. Zhenhua Gu (right) studied chemistry at Nanjing University and received his PhD degree in Shanghai Institute of Organic Chemistry in 2007 with Prof. Shengming Ma. He conducted his postdoctoral research at University of California Berkeley and University of California at Santa Barbara. In 2012, he began his independent academic career at the USTC with the support of "Thousand Talents Plan". Research in his group is mainly focused on the development of new methods for asymmetric atropisomers and their related natural products synthesis.
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