Increasing evidence shows that abnormal microRNA (miRNA) expression is involved in tumorigenesis. MiR-25 was previously reported to act as tumor suppressor or oncogene in diverse cancers. However, their expression, function, and mechanism in gastric cancer (GC) are not well known. Here, we show that miR-25 was overexpressed in primary tumor tissues of GC patients and was significantly correlated with a more aggressive phenotype of GC in patients. MiR-25 inhibition significantly decreased the proliferation, invasion, and migration of GC cells in vitro. Furthermore, miR-25 repressed F-box and WD-40 domain protein 7 (FBXW7) expression by directly binding to 3-untranslated region (UTR) of FBXW7, and the inverse correlation was observed between the expressions of miR-25 and FBXW7 mRNA in primary GC tissues. Moreover, the restoration of FBXW7 led to suppressed proliferation, invasion, and migration of GC cells. In vivo, miR-25 promotes tumor growth of GC. Taken together, miR-25 promotes GC progression by directly downregulating FBXW7 expression and may be employed as a novel prognostic marker and therapeutic target of GC.

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In this study, sodium chloride and sodium sulphate were used for investigating their effects on photocatalytic decomposition of a triazo acid dye, CI Acid Black 234, used widely for the coloration of leather and wool products by the Fe III -oxalate complexes ⁄ hydrogen peroxide system under different weather conditions, respectively. Moreover, the photocatalytic degradation and mineralisation of CI Acid Black 234 was also examined by ultraviolet-visible spectrum and total organic carbon measurements. The results indicated that photocatalytic decoloration of CI Acid Black 234 was significantly limited in the presence of inorganic salt. Increasing the concentration of inorganic salt led to a lower decoloration percentage and kinetic reaction constant. The effect of inorganic salt on dye decomposition varied with solar light intensity. Sodium chloride exhibits a much stronger reduction effect on photocatalytic decoloration, degradation and mineralisation than sodium sulphate at similar reaction conditions, especially on a cloudy day.