A palladium-catalyzed general synthetic strategy to access an attractive and decorated set of spirooxazinane skeletons was successfully achieved using vinyl benzoxazinanone derivatives and ketones.
Hydropyrrolo[2,3-b]indole is a privileged
indoline
motif, while its analogue, hydropyrrolo[3,2-b]indole,
has been much less explored. Herein, we developed a cascade reaction
of oxindole-derived nitrones with allenoates, providing straightforward
access to the tetracyclic hydropyrrolo[3,2-b]indole
scaffolds. Formation of multiple C–C/C–X bonds and cleavage
could be achieved within one synthetic step using a simple catalyst
(Gimeracil) under mild conditions. The reaction pathway may involve
the generation of spiro-hydroazepinone as the key intermediate.
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