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To observe the efficacy of Yougui pill combined with diacerein on gonitis and the effects of serum Tolllike receptor 4, matrix metalloproteinase-3 and nitric oxide. A total of 132 patients with gonitis treated in our hospital from January 2019 to October 2020 were selected and divided according to their treatment regimen. Efficacy: After 8 w of treatment, 28 patients had complete remission in the observation group, accounting for 42.42 %, 25 patients had partial remission, accounting for 37.88 % and 8 patients had remission, accounting for 12.12 %; in the control group, 14 patients had complete remission, accounting for 21.21 %, 21 patients had partial remission, accounting for 31.82 % and 18 patients had remission, accounting for 27.27 %; in the observation group, the overall response rate was higher than that in the control group and it was statistically significant (p<0.05). Serum: After 8 w of treatment, Toll-like receptor 4, matrix metalloproteinase-3 and nitric oxide, erythrocyte sedimentation rate and C-reactive protein in both groups were largely decreased compared with those before treatment (p<0.05) and after 8 w of treatment in the observation group, Toll-like receptor 4, matrix metalloproteinase-3 and nitric oxide, erythrocyte sedimentation and C-reactive protein were lower compared with the control group (p<0.05). Bone and joint function: The pain, daily activities, stiffness and total scores in both groups after 8 w of treatment were greatly decreased compared with those before treatment (p<0.05) and the above scores were lower in the observation group after 8 w of treatment compared with those in the control group (p<0.05). Safety: In the observation group, gastric discomfort occurred in 2 patients, dry mouth in 3 patients and fatigue in 1 patient; in the control group, gastric discomfort occurred in 2 patients and dry mouth in 1 patient; the rate of adverse effects in the observation group was not statistically different from that in the control group (p>0.05). The combination of Yougui pill and diacerein improved the efficacy and decreased the expression of serum related factors without increasing adverse effects in patients with gonitis.

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