Conjugated polymers and oligomers have great potentials in various fields, especially in materials and biological sciences because of their intriguing electronic and optoelectronic properties. In recent years, the through-space conjugation system has emerged as a new assembled pattern of multidimensional polymers. Here, a novel series of structurally condensed multicolumn/multilayer 3D polymers and oligomers have been designed and synthesized through one-pot Suzuki polycondensation (SPC). The intramolecularly stacked arrangement of polymers can be supported by either X-ray structural analysis or computational analysis. In all cases, polymers were obtained with modest to good yields, as determined by GPC and 1H-NMR. MALDI-TOF analysis has proven the speculation of the step-growth process of this polymerization. The computational study of ab initio and DFT calculations based on trimer and pentamer models gives details of the structures and the electronic transition. Experimental results of optical and AIE research confirmed by calculation indicates that the present work would facilitate the research and applications in materials.

Trimethoprim (TMP) is an active pharmaceutical ingredient with poor aqueous solubility. Here, we describe the cocrystallization of TMP with five co-formers, three bipyridines and two monopyridines. Cocrystallization of TMP with the bipyridines yields neutral cocrystals, and while both components are present in the lattice, they do not interact with each other via any strong intermolecular forces. Conversely, cocrystallization of TMP with the monopyridines yields salts, and included water or solvent molecules that play a key role in supramolecular assembly. Moreover, the salts exhibit significantly higher aqueous solubility than that of TMP. Two solids feature a compound on the Generally Recognized as Safe list, making them promising as ionic pharmaceutical cocrystals.

Co-crystallization of the pharmaceutical contaminants mefenamic acid and naproxen is reported; one co-crystal exhibits a rare carboxylic acid–pyridine synthon breakdown.