Flow-induced motions (FIM) of an elastically mounted circular cylinder with roughness strips at different angles of attack are investigated by 2-D URANS simulations based on the open source CFD tool OpenFOAM. The cylinder is constrained to one degree of freedom motion in the transverse direction. Two selectively distributed roughness strips on cylinder surface are used to enhance the FIM of the cylinder. Simulations are conducted at Re = 60,000 and Re = 100,000 with the angle of attack, αattack, varies from 0° to 90°. Amplitude response, frequency response, and near-wake structures of the cylinder are discussed in numerical results. The simulation results indicate that both suppression and enhancement of FIM are observed for the cylinder as the angle of attack rises from 0° to 90°. For αattack≥ 55°, the near-wake region becomes quite slender and vortex shedding is suppressed. The FIM of the cylinder is greatly inhibited when αattack ≥55°. In addition, a complex vortex reattachment observed in the near-wake region intensifies the fluid-structure interactions and causes obviously higher amplitude.