The pulmonary toxicity, induced by multi-wall carbon nanotubes in mice, was studied after 30-day and 60-day inhalation exposure. The mice were exposed to multi-wall carbon nanotubes aerosol with weighted mean concentration of 32.61 mg/m3, once in very two days, 6 hours in an exposure day. After 30-day and 60-day inhalation exposure, the pulmonary toxicity of multi-wall carbon nanotubes was assessed using biochemical indices in bronchoalveolar lavage fluid and pathological examination. It was found that the aerosolized multi-wall carbon nanotubes did not induce obvious pulmonary toxicity in 30-day exposure group, but induced severe pulmonary toxicity in 60-day exposure group.

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Background: To investigate the effect of the personality traits on development of acute mountain sickness (AMS). Met hods: One hundred and eighty-nine healthy m ale subjects transported from the plains (Chengdu, China) to high altitude area (Tibet, China) were enrolled in this study. Ninety-six subjects experienced AMS within two days after arriving at the Tibet plateau (AMS group). There were 93 subjects without AMS (healthy control without AMS group). The symptoms of AMS, state trait anxiety and personality traits of subjects were assessed using selfassessment and AMS questionnaire (Chinese criteria). Result s: The AMS group had a significantly higher prevalence of self-assessed anxiety, compared with the healthy control group without AMS. Personality traits estimation based on data obtained by Eysenck personality questionnaire revealed higher neuroticism and extraver-sion scores in the AMS group. Neuroticism, extraversion and anxiety level expressed highly significant levels of mutual concordance. Conclusion: The anxiety level was the highest in patients with AMS and it corroborated with neuroticism and extraversion level from the Eysenck scale. Psychological disturbances and extra-version can affect the development of AMS in rapid entry population. It would be helpful for people with anxiety-trait or personality traits to deal with the stress, in order to decrease the risk of developing AMS.