Eighty percent of patients with Parkinson's disease (PD) demonstrate dysfunctions in various motor status switches, such as difficulties in standing up, gait initiation, and freezing while walking. 1 These dysfunctions are the first intrinsic causes associated with falls and are closely related to cognitive impairment, often leading to restrictions in the patient's quality of life. [2][3][4] In addition, with disease progression, these dysfunctions are resistant to dopaminergic treatment and deep brain stimulation (DBS). 5,6 Therefore, revealing the neurophysiological patterns underlying different motor statuses, including sitting, standing, walking, dual-task walking, and freezing of gait, is essential for developing the optimized therapy.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.