To protect data privacy, users prefer to store encrypted data in cloud servers. Cloud servers reduce the cost of storage and network bandwidth by eliminating duplicate copies. To address the potential internal data leakage problem, the concept of clustering deviation is proposed for the first time. We improve the DBSCAN algorithm to tolerate clustering deviation. A data deduplication scheme is built upon the new algorithm, which considers users as clustering samples. Instead of immediately re-clustering new users, a certain deviation is tolerated to assign the users to the existing classes. We determine the popularity of the data according to user clustering results and apply different encryption schemes to protect the security of unpopular data more effectively. The performance of the algorithm is analyzed and compared with other methods through experiments, and the results verify the feasibility and efficiency of the proposed deduplication scheme.

-Ischemic-hypoxic condition for local osteoblasts and bone mesenchymal stem cells during bone fracture inhibits bone repairing. N-methyl pyrrolidone (NMP) has been approved as a safe and biologically inactive small chemical molecule, and might be useful for bone fracture repairing. In the present study, we investigated the effect of NMP on the hypoxia-reduced cellular viability and the expression of differentiation-associated markers, such as bone morphogenetic protein 2 (BMP-2), propeptide of type I procollagen I (PINP), alkaline phosphatase (ALP) or runt-related transcription factor 2 (Runx2) in the osteoblasts, and then we examined the molecular mechanism underlining such effect in the human osteoblastic hFOB 1.19 cells. Our results demonstrated that NMP significantly blocked the hypoxia-induced cell viability reduction and inhibited the hypoxia-caused expression downregulation of BMP-2, PINP, ALP and Runx2 in hFOB 1.19 cells. Then we confirmed the involvement of nuclear factor κB (NF-κB) pathway in the regulation by NMP on the hypoxia-mediated the reduction of osteoblast differentiation. The upregulated expression and transcriptional activity of NF-κB, while the downregulated inhibitory κB expression by the hypoxia treatment was reversed by the treatment with 10 mM NMP. In conclusion, our study found a protective role of NMP in osteoblast differentiation in response to hypoxia, and such protection was through inhibiting the NF-κB signaling. This suggests that NMP might be a protective agent in bone fracture repairing.

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Wrist and finger fractures detection is always the weak point of associate study, because there are small targets in X-rays, such as hairline fractures. In this paper, a dataset, consisting of 4346 anteroposterior, lateral and oblique hand X-rays, is built from many orthopedic cases. Specifically, it contains a lot of hairline fractures. An automatic preprocessing based on generative adversative network (GAN) and a detection network, called WrisNet, are designed to improve the detection performance of wrist and finger fractures. In the preprocessing, an attention mechanism-based GAN is proposed for obtaining the approximation of manual windowing enhancement. A multiscale attention-module-based generator of the GAN is proposed to increase continuity between pixels. The discriminator and the generator can achieve 93% structural similarity (SSIM) as manual windowing enhancement without manual parameter adjustment. The designed WrisNet is composed of two components: a feature extraction module and a detection module. A group convolution and a lightweight but efficient triplet attention mechanism are elaborately embedded into the feature extraction module, resulting in richer representations of hairline fractures. To obtain more accurate locating information in this condition, the soft non-maximum suppression algorithm is employed as the post-processing method of the detection module. As shown in experimental results, the designed method can have obvious average precision (AP) improvement up to 7% or more than other mainstream frameworks. The automatic preprocessing and the detection net can greatly reduce the degree of artificial intervention, so it is easy to be implemented in real clinical environment.

Tunnels account for an increasing proportion of highways. Due to the semi-closed structure of tunnels, signal communication is difficult in tunnels. This review analyzes the signal data transmission requirements of intelligent network management systems, such as lighting systems, wind protection systems, fire protection systems, and vehicle and pedestrian positioning systems in tunnels. The selection of signal coverage and transmission methods are also discussed. The advantages and disadvantages of various networking methods are analyzed. This paper summarizes the wireless signal transmission, wired signal transmission and signal transmission modes of different tunnel types.