This study assessed the antibacterial properties of aqueous, acetone and ethanolic extracts of Tetrapleura tetraptera pod. The samples were bought from Swali market in Yenagoa, Bayelsa state, Nigeria. Water (aqueous), acetone and ethanol were used for the extraction. Agar well diffusion sensitivity testing was employed for the study. Zone of inhibition results for Escherichia coli, Pseudomonas species, Staphylococcus aureus and Proteus species were 8.00mm, 8.00mm, 8.67mm and 9.00mm, respectively for aqueous extracts, 9.33mm, 9.00mm, 11.67mm and 10.00mm, respectively for acetone extracts, and 13.00, 11.33mm, 13.33mm and 12.00mm, respectively for ethanolic extracts. Analysis of variance showed that there was no significant difference (P > 0.05) in the zone of inhibition across the various isolates for aqueous, acetone and ethanolic extracts of Tetrapleura tetraptera pod. Based on comparison of the efficacy of the extracts with Ampiclox, the activities were in the statistical order: aqueous< acetone < ethanol
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