Currently most of the energy consumed in the world comes from sources such as coal, oil and natural gas. In recent decades the increase in demand for oil and natural gas has resulted in a large increase in the use of steel tubes to transport these products over long distances. High strength low alloy (HSLA) steels produced according to the API 5L standard are attractive for these applications because they have good mechanical properties and weldability combined with low costs. However, in these applications the materials are exposed to corrosive media with high levels of H 2 S, making them susceptible to damage caused by hydrogen. Among them, one of the most important is hydrogen-induced cracking (HIC). In this work the resistance to corrosion and HIC of two API 5L X65 steels, whose compositions differ mainly with respect to their Mn and Nb contents, and a commercial API 5L X80 steel were investigated in solution A of the NACE standard TM0284-2011. The evaluation of the corrosion resistance was carried out in naturally aerated or in deaerated solution without and with saturation with H 2 S by means of open circuit potential tests, potentiodynamic polarization curves and electrochemical impedance spectroscopy (EIS). Microstructural analysis by optical microscopy (OM) and scanning electron microscopy (SEM) were performed to correlate the microstructure with the two investigated parameters. OM and SEM analyzes showed that the two API 5L X65 steels have inclusions evenly distributed in a ferritic matrix with degenerated perlite islands and M/A (martensite/austenite) microconstituents at the perlite grain boundaries. In turn, the API 5L X80 steel presented a ferritic matrix with M/A microconstituents and round-shaped and irregular-shaped inclusions in greater number and irregularly distributed. The results of the electrochemical tests showed that, for all three steels, the corrosion resistance decreases significantly in the presence of H 2 S. On the other hand, the EIS tests showed an increase in corrosion resistance with immersion time in all media, which is probably due to the formation of insoluble corrosion products that precipitate on the steels surfaces. All assays showed that the two API 5L X65 steels are more resistant to corrosion than the API 5L X80 steel. The HIC assays showed that the two API 5L X65 steels are not susceptible to this type of failure, unlike the API 5L X80 steel. In the latter there was cracks formation in the central and lower (inner) part of the sample supplied as a tube. The analysis of the crack propagation path showed the presence of Mn and Srich inclusions, indicating that they play a key role in the cracking mechanism. The results of all corrosion tests showed that the experimental steel API 5L X65 produced by CBMM with low Mn contents and high levels of Nb exhibited slightly higher corrosion resistance than the API 5L X65 commercial steel, indicating that this composition is promising for sour media applications.