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Background: Essential thrombocythemia (ET) is a Philadelphia chromosome-negative myeloproliferative neoplasm characterized by sustained thrombocytosis and megakaryocytic hyperplasia. It is an uncommon hematological malignancy which primarily affects elderly individuals. The rational of this study was to determine its clinico-hematological profile along with risk stratification in Pakistan patients. Materials and Methods: In this retrospective cross sectional study, 21 patients with ET were enrolled from January 2011 to December 2014. Data was analyzed with SPSS version 21. Results: The mean age was 56.7±19.0 years (range 18-87) and the male to female ratio was 1:1.1. Of the total, 62% of patients were above 50 years of age. Overall 61.9% were diagnosed incidentally and were asymptomatic. In symptomatic patients, major complaints were weakness (19%); erythromelalgia (14.2%), transit ischemic attack (9.5%) and gastrointestinal bleed (4.7%). The mean hemoglobin count was 11.7±2.4 g/dl with a total leukocyte count of 13.3±8.1x10 9 /l and platelets count of 1188.8±522.2x10 9 /l. Serum lactate dehydrogenase, serum creatinine and uric acid were 454.3±127.8, 1.2±0.5 and 7.4±3.4 respectively. According to risk stratification, 57.1% were in high risk; 23.8% in intermediate risk while 19.1% in low risk group. Conclusions: ET in our patients in Pakistan, unlike in the West, is seen in a relatively young population. Primarily patients were asymptomatic and risk stratification revealed predominance of high risk disease in our setting.

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The WHO named the COVID-19 epidemic, which was caused by the SARS-CoV-2 coronavirus, a global pandemic on March 11, 2020. Doctors noted an increase in incidences of Mucormycosis towards the beginning of May 2020. Case Presentation: A 48-year-old female patient complained of fever, body aches, vomiting, abdominal pain, diarrhea and no weakness or numbness. A chest x-ray revealed bilateral pneumonia. Treatment with steroids, antibiotics, remdesivir and anticoagulation was initiated. Patient was diagnosed with sinusitis with right orbital cellulitis, moderated proptosis and frank osseous erosions. Concomitantly patient developed a scrapable black eschar on the upper palate. Patient further underwent FESS surgery of the maxillary sinuses of both sides. Patient was sent home after an appreciable recovery and put on a close follow up list. Conclusion: Diabetes mellitus sufferers are particularly susceptible to this fungus's deadly effects. For individuals with mucromycosis, swift and precise diagnostic facilities, medical aid and a speedy yet coordinated response are all recommended.