1) Daily infusion of physiological saline into peritoneal cavity may increase the peritoneal lymphatic flow; 2) The significant (apparent) increase in IPV shortly after infusion may suggest increased RISA binding to peritoneal tissues (which may be related to the damage of the tissues, and results in overestimation of the peritoneal fluid absorption rate); 3) Saline is not a biocompatible peritoneal dialysis solution, and should therefore not be used as a control or flush solution.

BACKGROUNDDeveloped from positive psychology, Psychological Capital (PsyCap) entails a collection of intrinsic traits which may be optimized for productive and sustainable outcomes in life. This systematic review explores potential virtual implementation of PsyCap interventions, especially given the digital transition amidst the COVID-19 pandemic and its potential usage in the future.METHODSUtilizing a mixed-methods systematic review, this convergent integrated synthesis involves database searches conducted in APA PsychINFO, Web of Science and PubMed with literature published between 1995 and 2020. This systematic review follows the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines with a registered PROSPERO protocol. With diverse study designs and accompanying grey literature, heterogeneity precluded statistical analysis for qualitative presentation of included studies. Study screening, extraction, and quality appraisal (using the Mixed Methods Appraisal Tool) were performed by two authors independently and reconciled. Disagreements were resolved by a third author.RESULTSPresent literature has determined effective increase of PsyCap with the PCI Intervention Model. Strengths-based interventions assisted in identifying individual recognition in strengths to maximize potential and increase PsyCap. Other interventions have been found to support hope, self-efficacy, resilience, or optimism (HERO).CONCLUSIONOverall, interventions from included studies showed effective improvement in HERO elements and increased PsyCap in individuals in academia and the workplace. In the context of the COVID-19 pandemic and future application, PsyCap interventions may be further explored and modified for virtual implementation for young adults.

<p></p><p>One of the main reasons of rapidly growing cases of COVID-19 pandemic is the unavailability of approved therapeutic agents. Therefore, it is urgently required to find out the best drug by all means. Aim of the current study is to test the anti-viral drug potential of many of the available olive and turmeric compounds that can be used as potential inhibitors against one of the target proteins of SARS-nCoV2 named Main protease (Mpro/3CLpro). Molecular docking of thirty olive and turmeric compounds with target protein was performed using Molecular Operating Environment (MOE) software, out of these 19 ligands were selected for redocking using PyRx to validate MOE results and to determine the best ligand-protein interaction energies. Molecular dynamics simulation was performed on best 7 docked complexes by NAMD/VMD to determine the stability of the ligand-protein complex. Out of the thirty drug agents, 6 ligands do not follow the Lipinski rule of drug likeliness by violating two or more rules while remaining 24 obey the rules and included for the downstream analysis. We found that Demethyloleoeuropein, Oleuropein, Rutin, Neuzhenide, Luteolin-7-rutinoside, Curcumin and Tetrehydrocurcumin gave best docking score and form much stable complexes during simulation. Our predictions suggest that these ligands have the potential inhibitory effects on Mpro of SARS-nCoV2, so, these herbal plants would be helpful in harnessing COVID-19 infection as home remedy with no serious known side effects. Further, in-vivo experimental studies are needed to validate the inhibitory properties of these compounds against the current and other target proteins in SARS-nCoV2.<b></b></p><br><p></p>

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