As a non‐invasive treatment modality with high tissue‐penetration depth, ultrasound‐triggered sonodynamic therapy (SDT) has been extensively explored and is regarded as the alternative choice to overcome the drawbacks of conventional photo‐triggered therapies. Nevertheless, the low quantum yield of sonosensitizer, tumor hypoxia, and undesirable therapeutic efficiency are still the major concerns of SDT. It is highly challenging but necessary to explore the SDT‐based synergistic, augmented, and noninvasive therapeutic modalities. Herein, a distinct TiO2Fe3O4@PEG Janus nanostructure composed of the typical sonosensitizer TiO2 and nanoenzyme Fe3O4 is rationally designed and engineered for bilaterally enhanced SDT and chemodynamic therapy (CDT). The deposition of Fe3O4 component on the surface of TiO2 can not only endow the Janus nanosonosensitizers with Fenton‐catalytic activity to generate hydroxyl radicals (•OH) from tumor‐endogenous overexpressed H2O2 for CDT but also enhance the SDT performance of TiO2 via narrowing the band gap of TiO2 and reducing the recombination rate of the electrons (e–/h+) pair. In turn, the US activation can both accelerate mass transfer and chemical reaction rates of the Fenton reaction to enhance the CDT effect. The high efficacy of bilaterally enhanced SDT and CDT is systematically demonstrated both in vitro and in vivo.
Nanosonosensitizer, Ce6-PTX@IR783, successfully realized the photoacoustic imaging-guided synergistic chemo–sonodynamic therapy with ultrasound-trigged controllable drug release and acquired high therapeutic efficacy for cancer.
Two-dimensional (2D) nanomaterials have received ever-increasing attention and in-depth exploration in multifarious fields on account of their superior mass transfer ability and abundant catalytic-active sites. Especially, the amorphous 2D nanomaterials feature unique properties distinct from atomic crystalline materials. However, the synthesis of high-quality and large-sized amorphous 2D nanomaterials encounters a big challenge. Here, a general and facile synthetic strategy for a series of 2D amorphous metal and nonmetallic oxides nanosheets, including SiO2, AlOOH, ZrO2 and TiO2 nanosheets, is reported. The versatile 2D amorphous nanomaterials are fabricated via manipulating the surface energy of relevant metal alkoxide precursors with liquid feature and controlling the related synthesis parameters to form solid 2D amorphous nanosheets by in situ hydrolysis and condensation of precursors. Density functional theory (DFT) calculations reveal the molecular adsorption mechanism of wetting process of precursor infiltrated on solid NaCl substrate resulting from the strong interaction between Na-O atom pairs from NaCl and metal alkoxides respectively. Furthermore, taking the 2D Fe-ZrO2 nanomaterials as the catalyst, the excellent catalytic performance for Rhodamine B (RhB) degradation illustrates that these 2D nanomaterials prepared by this method have the characteristics of easy functionalization. This work provides an efficient strategy for nanomaterials functionalization during 2D nanosheets synthetic process and further being applied in catalysis-related field and beyond.
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