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The mass spectra of fifteen B-carbolines have been interpreted and proposed fragmentations have been substantiated by means of deuterium-labeling and accurate mass determinations. Most decompositions were predictable. An interesting fragmentation was observed in the spectra of 1 -alkyl-l,2,3,4-tetrahydro-~-carbolines, which rearrange to expel an alkylamino (RNH) radical from the molecular ion. 157 230-20 -

The mass spectra of the following common anti-epileptic agents; phensuximide, methsuximide, ethosuximide, ethotoin, mephenytoin, diphenylhydantoin, trimethadione, paramethadione, primidone and phenacemide, have been recorded and interpreted. In addition the mass spectra of succinimide, a-phenylsuccinimide and the N-deuterated derivative of ethotoin were studied. The investigated compounds fragment in an interesting manner and give rise to stable ions by which means they are readily identified. The most diagnostic fragmentation in the majority of the spectra was the expulsion of a (CO),NR fragment from the molecular ion.

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