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Pressure loss for flow of a steam-water mixture in a pebble bed is experimentally investigated (the first stage of the study was described in Avdeev, et al., 2003 [High Temp., 41, pp. 371–383]). The measurements of the care performed within the wide range of regime parameters: pressures of 0.9-15.6MPa, mass-flow rates of 107-770kg∕(m2s) and steam quality of 0–0.49. The experimental data for the pressure loss of single-phase air and water flows were used as reference data. The final results are represented in the form of the ratio of the pressure loss for the steam-water flow to that for the single-phase water flow at identical mass-flow rates.