Objectives: To describe CT imaging features of 4 patients with initial negative RT-PCR results but high suspicion of COVID-19 infection. Materiel and methods: Retrospective study including patients with COVID-19 pneumonia who underwent both CT and RT-PCR at initial presentation in our institution From March 31th, 2020 to april 27 th .The results of both tests were compared. For patients with a final confirmed diagnosis ,clinical , laboratory data and CT imaging findings were evaluated. Results: From 142 laboratory confirmed cases, a total of four patients had an initial negative RT PCR and positive CT findings . 3 patients were diagnosed in early stage (1-5days) and one in progressive stage (5-8 days). The 4 patients had typical imaging findings, including groundglass opacity (GGO) (2 patients) ,crazy paving (1 patient),mixed GGO and crazy paving (1 patient) .All the patients were isolated After for presumed 2019-nCoV pneumonia and they were eventually confirmed with 2019-nCoV infection by repeated swab tests. Conclusion: rRT-PCR may produce false-negative results in the early stages of the disease mostly. We therefore suggest that CT features could be utilized as the immediate reference to screen the highly suspected cases and to take necessary actions, while rRT-PCR serves as a confirmation tool to decide the subsequent action of continuing isolated treatment or discharge. Key points: Typical radiological presentation with high clinical suspicion of 2019-nCov infection should be considered even do negative RT-PCR results .  In these cases,repeat swab testing and patient isolation should be applicable.

Background: Infection with the novel coronavirus, named Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), producing a clinical syndrome known as COVID-19, is a budding infectious disease that first manifested in December 2019 in China and subsequently spread worldwide. Objectives: We performed an analysis of cardiac injury markers to determine their usefulness as predictors of severity and mortality Methods: In a retrospective study, we enrolled 73 patients with confirmed diagnoses of COVID-19, from March 21, 2020, to April 24, 2020. Serial tests of cardiac injury markers, including cardiac troponin I (cTnI), N‐terminal pro‐brain natriuretic peptide (NT‐proBNP), and Lactate dehydrogenase (LDH), were considered for the analysis of potential cardiac damage. Results: Among 149 patients with confirmed COVID-19, data from 73 patients were studied. Of them, 58 (79.46%) patients were discharged, and 15 (20.54 %) patients died. The mean age was 58.50 (14.66) years. Patients were classified into mild (39 cases), severe (17 cases), and critical (17 cases) groups. The peak cardiac troponin I level (0.11 ng/mL [IQR: 0.33–0.20]), peak NT-pro BNP level (5840.35 pg/mL [IQR: 1609.39 – 10071.32]), and peak LDH level (578.65 UI/l[IQR: 313.40 – 843.90]) were significantly higher in the critical group, and the three cardiac injury parameters were significantly higher in the death group, suggesting that they are significantly associated with a higher risk of in-hospital mortality. Conclusions: The understanding of cardiovascular system injury caused by SARS-CoV-2 and its underlying mechanisms is of great importance for the early clinical management of these patients and mortality reduction.

During the COVID-19 pandemic, the effectiveness of the combination of hydroxychloroquine and azithromycin is widely discussed. This treatment can cause many severe cardiac side effects that makes us discuss its utility. The aim of this study is to describe the cardiovascular effect of hydroxychloroquine and azithromycin by analyzing surface ECG in patients with COVID-19. This observational cohort study included Moroccan patients with COVID-19 diagnosis and were hospitalized in

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