Access to safe, nutritious, and sufficient food is essential to ensure food and nutrition security and healthy lives for all. Secure access to nutritious food ensures healthy eating habits, economic growth, and stability in an economy. However, food insecurity and malnutrition persist globally. In Ghana, more than half of food-insecure people reside in the Northern ecological zones of the country. Moreover, Ghana lacks a systematic food security monitoring system to track food insecurity among vulnerable populations. This study reviewed existing evidence on the current situation and changes related to food production, trade, safety, and consumption in Ghana, as part of the process to develop food-based dietary guidelines for the country. The literature review included peer-reviewed articles published from 2010 – 2020 in Ghana to document household-level food production, consumption, and safety issues. In addition, food disappearance data (from 2010 to 2018) from the Food and Agriculture Organization of the United Nations was analysed. Means and compound annual growth rates were calculated for each food item included. The results showed that per capita food production was higher than per capita consumption in all the food categories studied, except for vegetables, and fish and fishery products. Food consumption was centred on a few priority staple crops such as cassava, maize, rice, and yams, with less consideration given to underutilised foods such as akokono (palm weevil larvae). Food imports exceeded food exports in all food categories except 1) cocoa beans and products, 2) root crops and tubers, 3) oil-bearing crops and nuts, and 4) fruits and products. Fruit and vegetable consumption in Ghana has been declining since 2013. There was also a rise in the import and consumption of processed foods, especially tomato paste, sugars, and alcoholic and non-alcoholic beverages. Food safety issues included microbial contamination, aflatoxin contamination, polycyclic aromatic hydrocarbons in smoked fish, mercury in fish, pesticide and heavy metal residues in vegetables and fruits, and food adulteration. The evidence synthesized from this study will be useful to inform the development of food-based dietary guidelines for Ghana. Key words: Food, production, trade, consumption, food security, safety, Ghana